Summary
Performance
Immunogen
Application
Background
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009],function:Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.,induction:By oxidative stress.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Maf subfamily.,similarity:Contains 1 bZIP domain.,subunit:Monomer and homo- or heterodimer. Interacts with MIP.,tissue specificity:Expressed in the term myometrium and kidney.,
Research Area
Epigenetics and Nuclear Signaling; Transcription; Domain Families; HLH / Leucine Zipper; Leucine Zipper; Transcription Factors; Chromatin Binding Proteins; DNA / RNA binding; Cell Biology; Other Antibodies; Oxidative Stress; Metabolism; Pathways and Processes; Redox metabolism
