NUMB Rabbit Monoclonal antibody

NUMB Rabbit Monoclonal antibody

SKU: AMRe04093 ★ ★ ★ ★ ★
Size1:50μL Price1:$188 $99
Size2:100μL Price2:$338 $180
Application:WB,IHC-P,IP
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:NUMB Category: Recombinant Monoclonal Antibody Tags: , , , , , , , , ,

Summary

Production Name

NUMB Rabbit Monoclonal antibody

Description

Recombinant Rabbit Monoclonal antibody

Host

Rabbit

Application

WB,IHC-P,IP

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Purification

Affinity Purified

 

Immunogen

Gene Name

NUMB

Alternative Names

NUMB; Protein numb homolog; h-Numb; Protein S171

Gene ID

8650

SwissProt ID

P49757

 

Application

Dilution Ratio

WB: 1:500-1:1000 IHC: 1:50-1:100 IP: 1:20

Molecular Weight

Calculated MW: 71 kDa; Observed MW: 71 kDa

 

Background

Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.

 

Research Area

Signal Transduction

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