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PHD2/prolylhydroxylase Rabbit Monoclonal Antibody

PHD2/prolylhydroxylase Rabbit Monoclonal Antibody

Cat: AMRe83982
Size:50μL Price:$168
Size:100μL Price:$300
Application:WB,IP
Reactivity:Human
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:PHD2/prolylhydroxylase Category: Recombinant Monoclonal Antibody Tags:

Summary

Production Name

PHD2/prolylhydroxylase Rabbit Monoclonal Antibody

Description

Recombinant rabbit monoclonal antibody

Host

Rabbit

Application

WB,IP

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Purified antibody in PBS with 0.05% sodium azide,0.05% protective protein and 50% glycerol.

Purification

Affinity Purification

 

Immunogen

Gene Name

PHD2/prolylhydroxylase

Alternative Names

EGLN1; C1orf12; ECYT3; HIFPH2; HPH2; PHD2; SM-20; SM20; ZMYND6;;PHD2

Gene ID

SwissProt ID

Q9GZT9

 

Application

Dilution Ratio

WB 1:1000-1:2000,IP 1:20-1:50

Molecular Weight

46 kDa

 

Background

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

 

Research Area

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