Phospho-mTOR (Ser2448) Rabbit Monoclonal Antibody

Summary

Production Name	Phospho-mTOR (Ser2448) Rabbit Monoclonal Antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,IHC
Reactivity	Human,Mouse

Performance

Conjugation	Unconjugated
Modification	Phosphorylated
Isotype	IgG
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Purified antibody in TBS with 0.05% sodium azide,0.05%protective protein and 50% glycerol.
Purification	Affinity Purification

Immunogen

Gene Name	Phospho-mTOR (Ser2448)
Alternative Names	MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar
Gene ID	2475
SwissProt ID	P42345

Application

Dilution Ratio	WB 1:500-1:1000,IHC 1:50-1:100
Molecular Weight	Calculated MW: 289 kDa; Observed MW: 289 kDa

Background

An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.

Research Area

PI3K-Akt signaling pathway,mTOR signaling pathway,Jak-STAT signaling pathway,Hippo signaling pathway