Summary
Performance
Immunogen
Application
Background
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 bromo domain.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 PWWP domain.,subunit:Interacts in vitro with PRKCB1.,tissue specificity:Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).,
Research Area
Epigenetics and Nuclear Signaling; Transcription; Domain Families; Zinc Finger; Signal Transduction; Protein Phosphorylation; Tyrosine Kinases; Receptor Tyrosine Kinases; Transcription Factors
