Summary
Performance
Immunogen
Application
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008],function:Mediates activation of NF-kappa-B. May play a role in T-cell activation.,PTM:Phosphorylated in vitro by OXSR1.,similarity:Belongs to the RELT family.,similarity:Contains 1 TNFR-Cys repeat.,subunit:Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.,tissue specificity:Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.,
Research Area
Cytokine-cytokine receptor interaction;
