Summary
Performance
Immunogen
Application
Background
Sox (Sry-related box) genes encode a family of transcription factors that play a myriad of roles in developmental processes. Sox1 and Sox2 are the earliest markers that identify neuroectodermal tissue, and these markers, together with Sox9 collectively mark neuronal stem cells (NSC's) that are present in neurogenically active areas of the mature rodent brain. Sox1 is thought to maintain the cell cycle and promote self renewal in NSCs. Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Research Area
