NuRD Complex
The transcriptional repressor NuRD (nucleosome remodeling and histone deacetylase) complex is composed of multiple subunits, which include CHD3 (also known as Mi2-α), CHD4 (also known as Mi2-β), HDAC1, HDAC2, RBAP48, RBAP46, MTA1, MTA2, MTA3, and MBD3. Both CHD3 and CHD4 contain two PHD (plant homeodomain) zinc finger domains that bind directly to HDAC1 and HDAC2. HDAC1 and HDAC2 are highly homologous and are involved in histone deacetylation, chromatin remodeling and transcriptional repression, and are also found together in the mSin3A and MeCP1 complexes. RBAP46 and RBAP48 bind to the histone fold region of histone H4 and are believed to target the NuRD complex to its histone substrates. MBD3, a member of the methyl-CpG-binding domain protein family, and the metastasis associated genes MTA1, MTA2, and MTA3 were all found to be integral components of the NuRD complex.
Schematic of NuRD
Relevent antibodies
| Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|
| AMRe08746 | CHD4 (15O2) Rabbit Monoclonal Antibody | Human,Mouse | WB,ICC/IF,FC,IP |
| AMRe21452 | HDAC1 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| AMRe21580 | HDAC2 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| AMRe84502 | MBD3 Rabbit Monoclonal | Human,Mouse,Rat | WB,IP,ICC,FC |
| AMM82255 | MTA1 Mouse Monoclonal Antibody | Human | WB,FC,ELISA |
| AMM82280 | RBBP7 Mouse Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC,FC,ELISA |
| APS0635 | HRP-conjugated Polyclonal Goat Anti-Rabbit IgG(H+L) Secondary Antibody | ||
| APS0631 | HRP-conjugated Polyclonal Goat Anti-Mouse IgG(H+L) Secondary Antibody | ||
| AMre80004 | GAPDH (12R9) Rabbit Monoclonal Antibody |
Related Products
References
- Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature. 1998 Oct 29;395(6705):917-21.[PMID: 9804427].
- Bowen NJ, Fujita N, Kajita M, Wade PA. Mi-2/NuRD: multiple complexes for many purposes. Biochim Biophys Acta. 2004 Mar 15;1677(1-3):52-7.[PMID: 15020045].
- Hoffmann A, Spengler D. Chromatin Remodeling Complex NuRD in Neurodevelopment and Neurodevelopmental Disorders. Front Genet. 2019 Jul 24;10:682. [PMID: 31396263].
 | Flora Flora is a technical support expert at EnkiLife, familiar with immunology and neuroscience, dedicated to providing customers with high-quality product combinations and technical support to help achieve research in neurodegenerative diseases and other neuroscience areas. |