TCF/LEF Family
TCF/LEF Family
LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors which consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1, also known as TCF7), TCF3 (also known as TCF7L1) and TCF4 (also known as TCF7L2). LEF1 and TCF1/TCF7 were originally identified as important factors regulating early lymphoid development that act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling. LEF1 and TCF proteins are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer.
Relevant antibodies
| Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|
| AMRe21151 | TCF7 Rabbit Monoclonal antibody | Human,Rat | WB,IHC,IF,IP,ELISA |
| AMRe83733 | TCF3 Rabbit Monoclonal | Human | WB,FC |
| AMRe02675 | Transcription Factor 7 Like 2 Rabbit Monoclonal Antibody | Human | WB,IHC-P,IP |
| AMRe21153 | LEF1 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| APS0635 | HRP-conjugated Polyclonal Goat Anti-Rabbit IgG(H+L) Secondary Antibody | ||
| AMre80004 | GAPDH (12R9) Rabbit Monoclonal Antibody |
Related Products
References
- Waterman ML. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):41-52.[PMID: 15000148].
- Schilham MW, Clevers H. HMG box containing transcription factors in lymphocyte differentiation. Semin Immunol. 1998 Apr;10(2):127-32.[PMID: 9618758].
- Kong Y, Ou X, Li X, Zeng Y, Gao G, Lyu N, Liu P. LGR6 Promotes Tumor Proliferation and Metastasis through Wnt/β-Catenin Signaling in Triple-Negative Breast Cancer. Mol Ther Oncolytics. 2020 Jun 24;18:351-359.[PMID: 32775619].
 | Flora Flora is a technical support expert at EnkiLife, familiar with immunology and neuroscience, dedicated to providing customers with high-quality product combinations and technical support to help achieve research in neurodegenerative diseases and other neuroscience areas. |