Tyro/Axl/Mer Activation
Axl, Mer and Tyro3 are three members of the TAM family receptor tyrosine kinase that share a common NCAM (neural adhesion molecule)-related extracellular domain and a conserved intracellular tyrosine kinase domain. These receptors bind common homologous vitamin K dependent protein GAS6 and protein S to activate downstream signaling pathways. TAM family receptors are involved in the development of immune, nervous, vascular and reproductive systems, autoimmune disease, cancer drug resistance and tumor immunity response. Axl (Tyr698), Axl (Tyr702), Mer Tyr(749) and Tyro3 (Tyr681) are conserved autophosphorylation sites located in the activation loop of the respective tyrosine kinase domains. Phosphorylation at these sites is required for full kinase activation of each of the corresponding receptors.
TAM receptor - ligand structure, and signaling in phagocytosis
Relevant Antibodies
| Catalog# | Product Name | Application | Reactivity |
|---|---|---|---|
| APRab04290 | Axl (phospho-Tyr702) Rabbit Polyclonal Antibody | WB | Human,Rat,Mouse |
| AMRe21059 | Axl Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe03084 | MERTK Rabbit Monoclonal Antibody | WB,IHC-P,IP | Human |
| AMRe19468 | TYRO3 (5G16) Rabbit Monoclonal Antibody | WB,IHC-P,IP | Human,Mouse,Rat |
| APRab11302 | Gas6 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Rat,Mouse |
| APS0635 | HRP-conjugated Polyclonal Goat Anti-Rabbit IgG(H+L) Secondary Antibody | ELISA,WB,Dotblot | Mouse |
| AMRe80004 | GAPDH (12R9) Rabbit Monoclonal Antibody | WB,ELISA | Human,Mouse,Rat,Rabbit,Dog,Monkey |
Related Products
· Super-sensitive ECL chemiluminescent reagent
· IHC Kit
References
- Rothlin, C.V. et al. (2015) Annu Rev Immunol 33, 355-91.
- Burstyn-Cohen, T. (2017) Int J Dev Biol 61, 215-24.
- Bellan, M. et al. (2016) Int J Mol Sci 17, pii: E1807.
- Schoumacher, M. and Burbridge, M. (2017) Curr Oncol Rep 19, 19.
- Akalu, Y.T. et al. (2017) Immunol Rev 276, 165-77.
- Ling, L. et al. (1996) J Biol Chem 271, 18355-62.
- Onken, J. et al. (2017) Oncotarget 8, 50403-14.
 | Voisey Voisey is a technical support specialist at EnkiLife, proficient in immunology and cell biology. She is committed to providing customers with professional and efficient technical support. Additionally, she is involved in research on customers' fields of study and designs highly cost-effective solutions for them. |