Wnt/β-Catenin Activated Targets Antibody
The Wnt family includes several secreted glycoproteins that play important roles in animal development. β-catenin is a key downstream effector of the Wnt signaling pathway that research studies have shown is implicated in early embryonic development and tumorigenesis in vertebrates (1-3). Following binding of Wnt family proteins to the Frizzled receptor, β-catenin translocates to the nucleus where it interacts with LEF1 and TCF1 to activate canonical targets (4). Accepted canonical targets include CD44, cyclin D1, c-Jun, c-Myc, Met, and MMP-7 (5-11).
The Wnt signaling pathway.
Relevant Antibodies
| Catalog# | Product Name | Application | Reactivity |
|---|---|---|---|
| AMRe21424 | CD44 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe21529 | Cyclin D1 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe21376 | c-Jun Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe21153 | LEF1 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe21182 | Met Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe21557 | c-Myc Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| AMRe21151 | TCF7 Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Rat |
| APS0635 | HRP-conjugated Polyclonal Goat Anti-Rabbit IgG(H+L) Secondary Antibody | ELISA,WB,Dotblot | Mouse |
| AMRe80004 | GAPDH (12R9) Rabbit Monoclonal Antibody | WB,ELISA | Human,Mouse,Rat,Rabbit,Dog,Monkey |
Related Products
· Super-sensitive ECL chemiluminescent reagent
· IHC Kit
References
- Cadigan, K.M. and Nusse, R. (1997) Genes Dev 11, 3286-305.
- Wodarz, A. and Nusse, R. (1998) Annu Rev Cell Dev Biol 14, 59-88.
- Polakis, P. (1999) Curr Opin Genet Dev 9, 15-21.
- Brantjes, H. et al. (2002) Biol Chem 383, 255-61.
- Zeilstra, J. et al. (2008) Cancer Res 68, 3655-61.
- Shtutman, M. et al. (1999) Proc Natl Acad Sci U S A 96, 5522-7.
- Mann, B. et al. (1999) Proc Natl Acad Sci U S A 96, 1603-8.
- Wilkins, J.A. and Sansom, O.J. (2008) Cancer Res 68, 4963-6.
- Boon, E.M. et al. (2002) Cancer Res 62, 5126-8.
- Brabletz, T. et al. (1999) Am J Pathol 155, 1033-8.
- Clevers, H. and Nusse, R. (2012) Cell 149, 1192-205.
 | Voisey Voisey is a technical support specialist at EnkiLife, proficient in immunology and cell biology. She is committed to providing customers with professional and efficient technical support. Additionally, she is involved in research on customers' fields of study and designs highly cost-effective solutions for them. |