Summary
| Production Name | Integrin alpha 2 Rabbit Monoclonal Antibody |
| Description | Recombinant rabbit monoclonal antibody |
| Host | Rabbit |
| Application | WB |
| Reactivity | Human |
Performance
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Clonality | Monoclonal |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Purified antibody in TBS with 0.05% sodium azide,0.05%protective protein and 50% glycerol. |
| Purification | Affinity Purification |
Immunogen
| Gene Name | Integrin alpha 2 |
| Alternative Names | ITGA2; CD49B; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD49b |
| Gene ID | 3673 |
| SwissProt ID | P17301 |
Application
| Dilution Ratio | WB 1:500-1:1000 |
| Molecular Weight | Calculated MW: 129 kDa; Observed MW: 150 kDa |
Background
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Research Area
PI3K-Akt signaling pathway