KD-Validated Phospho-4E BP1 (Thr46) Recombinant Rabbit Monoclonal Antibody
Size:20μL Price:$118
Size:50μL Price:$218
Size:100μL Price:$318
Application:WB,FCM,ICC,IHC-P

Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Gene Name:EIF4EBP1
SKU: KVAb00787
Detail

Summary

Production Name

KD-Validated Phospho-4E BP1 (Thr46) Recombinant Rabbit Monoclonal Antibody

Description

KD-Validated antibody

Host

Rabbit

Application

WB,FCM,ICC,IHC-P

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

Rabbit IgG

Clonality

Rabbit mAb

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Purification

Affinity purification

 

Immunogen

Gene Name

EIF4EBP1

Alternative Names

EIF4EBP1; Eukaryotic Translation Initiation Factor 4E Binding Protein 1; PHAS-I ; 4E-BP1; Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; EIF4E-Binding Protein 1; 4EBP1; BP-1

Gene ID

1978

SwissProt ID

Q13541

 

Application

Dilution Ratio

WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200

Molecular Weight

Calculated MW: 12.6kDa

 

Background

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

 

Research Area

Epigenetics and Nuclear Signaling,Metabolism

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