Summary
| Production Name | KD-Validated Phospho-4E BP1 (Thr46) Recombinant Rabbit Monoclonal Antibody |
| Description | KD-Validated antibody |
| Host | Rabbit |
| Application | WB,FCM,ICC,IHC-P |
| Reactivity | Human,Mouse,Rat |
Performance
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | Rabbit IgG |
| Clonality | Rabbit mAb |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide. |
| Purification | Affinity purification |
Immunogen
| Gene Name | EIF4EBP1 |
| Alternative Names | EIF4EBP1; Eukaryotic Translation Initiation Factor 4E Binding Protein 1; PHAS-I ; 4E-BP1; Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; EIF4E-Binding Protein 1; 4EBP1; BP-1 |
| Gene ID | 1978 |
| SwissProt ID | Q13541 |
Application
| Dilution Ratio | WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 |
| Molecular Weight | Calculated MW: 12.6kDa |
Background
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Research Area
Epigenetics and Nuclear Signaling,Metabolism