Summary
| Production Name | Thrombomodulin Rabbit Monoclonal Antibody |
| Description | Recombinant rabbit monoclonal antibody |
| Host | Rabbit |
| Application | WB,IHC,ICC/IF,FC,IP |
| Reactivity | Mouse |
Performance
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Clonality | Monoclonal |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% protective protein. Stable for 12 months from date of receipt. |
| Purification | Affinity Purification |
Immunogen
| Gene Name | Thrombomodulin |
| Alternative Names | TM; CD141; AI385582 |
| Gene ID | 21824 |
| SwissProt ID | P15306 |
Application
| Dilution Ratio | WB 1:500-1:2000,IHC 1:200-1:500,ICC/IF 1:100-1:200,FC 1:200-1:500,IP 1:20-1:50 |
| Molecular Weight | Calculated MW:62 kDa; Observed MW:105 kDa |
Background
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Research Area