HTRA3_MOUSE Q9D236
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UniProt:Q9D236
Recommended name：Serine protease HTRA3
EC number：EC 3.4.21.-
Alternative names：(High-temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease)
Cleaved into：
GeneID：78558
Gene names (primary )：Htra3
Gene names (synonym )：Prsp Tasp
Gene names (ORF )：
Length：459
Mass：49149
Sequence：MQARALLPATLAILATLAVLALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLECVRGVCRCRWTHTVCGTDGHTYADVCALQAASRRALQVSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSSTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATIVIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQNKHVKDWKKRFIGIRMRTITPSLVEELKAANPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLNESSLLLEVRRGNDDLLFSIIPEVVM
Tissue specificity：Highest level of isoform 1 in maternal part of the placenta, moderate level in heart, testis and ovary, low level in muscle and lung. High expression found in granulosa cells of the ovary. Expressed in bone matrix, particularly in articular chondrocytes. Very low level of isoform 2 expressed in placenta. Expressed in the bone matrix, particularly in articular chondrocytes. {ECO:0000269|PubMed:15206957, ECO:0000269|PubMed:15951015, ECO:0000269|Ref.2}.
Induction：Up-regulated during early pregnancy coinciding with placentation. Also up-regulated in joint cartilage affected by arthritis. {ECO:0000269|PubMed:12728021, ECO:0000269|PubMed:15206957}.
Developmental stage：First expressed at 9.5 dpc. Levels then increase until 14.5 dpc after which they remain high until newborn. First detected in the eye at 10.5 dpc and then expressed in tissues associated with skeletal tissue. At 12.5 dpc expressed in the vertebral rudiments in the tail region and, in the developing eye, in lens epithelium. At adulthood, expression found in the ganglion cell layer and the inner nuclear layer of the retina. In the developing heart at 16.5 dpc, expressed in the endocardial cushion. In the trachea at this stage, in outer layers and in the aorta, in adventitia. {ECO:0000269|PubMed:15206957, ECO:0000269|PubMed:15951015}.
Protein families：Peptidase S1C family