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IL25 molecular target information overview


  • Molecular name: IL25, interleukin 25
  • Gene family: Interleukins
  • Alias: IL-25; IL-17E
  • Former name: IL17E
  • Alias: interleukin 17E


    • Overview of IL25 molecular targets


    Interleukin 17E (IL-17E), also known as IL-25, is a member of the IL-17 family and is secreted by type 2 helper T cells (Th2) and mast cells. It is similar to IL-17 in sequence and can induce NF-κB activation and stimulate the production of IL-8. IL-17E and IL-17B are ligands for the cytokine receptor IL-17RB. Studies in mice have shown that IL-17E may be a proinflammatory cytokine that favors Th2-type immune responses. IL-17E induces the production of other cytokines in a variety of tissues, including IL-4, IL-5, and IL-13, thereby stimulating eosinophilia. This cytokine is an important molecule that regulates intestinal immunity and is involved in chronic inflammation associated with the gastrointestinal tract. IL-17E can kill certain types of breast cancer cells.


    Human IL25 molecular target information


    Molecular name: IL25, interleukin 25


    Alias:

    • IL-17E
    • IL-25
    • IL17E
    • interleukin 17E
    • interleukin-17E
    • interleukin-25

    Gene sequence:NCBI_Gene: 64806

    Protein sequence:UniProtKB: Q9H293


    Human IL25 target molecular function (prediction)


    Predicted to enable interleukin-17E receptor binding activity. Predicted to be involved in inflammatory response to antigenic stimulus and signal transduction. Predicted to act upstream of or within several processes, including eosinophil differentiation; response to fungus; and response to nematode. Predicted to be located in extracellular region. Biomarker of atopic dermatitis and psoriasis.


    Mouse Il25 molecular target information


    Molecular name: Il25, interleukin 25


    Alternate names:

    • IL-17E
    • Il17e
    • interleukin 17E


    Gene sequence:NCBI_Gene: 140806

    Protein sequence:


    Mouse Il25 target molecular function (prediction)


    Enables cytokine activity. Acts upstream of or within several processes, including eosinophil differentiation; response to fungus; and response to nematode. Predicted to be located in extracellular space. Orthologous to human IL25 (interleukin 25).


    Rat Il25 molecular target information


    Molecular name: Il25, interleukin 25

    Alias:

    • interleukin-25
    • LOC501996
    • RGD1561632
    • similar to IL25

    Gene sequence:NCBI_Gene: 501996

    Protein sequence:UniProtKB: D3ZLB1


    Rat Il25 target molecular function (prediction)


    Predicted to enable cytokine activity. Involved in inflammatory response to antigenic stimulus. Located in extracellular space. Biomarker of gastric ulcer. Orthologous to human IL25 (interleukin 25).