CREM_MOUSE P27699
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UniProt:P27699
Recommended name：cAMP-responsive element modulator
EC number：
Alternative names：(Inducible cAMP early repressor) (ICER)
Cleaved into：
GeneID：12916
Gene names (primary )：Crem
Gene names (synonym )：
Gene names (ORF )：
Length：357
Mass：38516
Sequence：MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHMQTGQISVPTLAQVSVAGSGTGRGSPAVTLVQLPSGQTVQVQGVIQTPHPSVIQSPQIQTVQVATIAETDDSADSEVIDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD
Tissue specificity：Expressed in the testis. {ECO:0000269|PubMed:26940607}.
Induction：Isoform 11 is expressed in a circadian manner in the adrenal gland with an expression peak at ZT20 (at protein level). It is induced by cAMP in an immediate-early fashion and can repress its own production via a negative autoregulatory mechanism. {ECO:0000269|PubMed:23443664, ECO:0000269|PubMed:8252624}.
Developmental stage：In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts.
Protein families：BZIP family