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GZMK molecular target information overview


  • Molecular name: GZMK, granzyme K
  • Gene family: Granule associated serine proteases of immune defence
  • Alias: TRYP2; PRSS
  • Alias: tryptase II; granzyme K (serine protease, granzyme 3; tryptase II); granzyme K (granzyme 3; tryptase II)


    • Overview of GZMK molecular targets


    Granzymes are serine proteases secreted by cytoplasmic granules released by cytotoxic T lymphocytes and natural killer cells. Granzymes can induce apoptosis of virus-infected cells, thereby killing them. Human granzymes include granzyme A, granzyme B, granzyme H, granzyme K and granzyme M. Granzyme K is encoded by the GZMK gene. The gene product is a member of a group of related serine proteases. Cytotoxic T lymphocytes and natural killer cells have a distinct ability to recognize, bind to and lyse specific target cells. They lyse cells carrying "non-self" antigens on their surfaces, which are usually peptides or proteins infected by intracellular pathogens, thereby protecting the host. Granzyme K lacks the consensus sequence involved in N-glycosylation in other granzymes. High levels of granzyme K are present in patients with sepsis.


    Human GZMK Molecular Target Information


    Molecular name: GZMK, granzyme K


    Alias:

    • fragmentin-3
    • granzyme 3
    • granzyme K (granzyme 3, tryptase II)
    • granzyme K (serine protease, granzyme 3, tryptase II)
    • granzyme-3
    • NK-Tryp-2
    • NK-tryptase-2
    • TRYP2
    • tryptase II

    Gene sequence:NCBI_Gene: 3003

    Protein sequence:UniProtKB: P49863


    Human GZMK target molecular function (prediction)


    Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region.


    Mouse Gzmk molecular target information


    Molecular name: Gzmk, granzyme K


    Alias:

    • None


    Gene sequence:NCBI_Gene: 14945

    Protein sequence:


    Mouse Gzmk target molecular function (prediction)


    Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Is expressed in brain; lung; small intestine; and spleen. Orthologous to human GZMK (granzyme K).


    Rat Gzmk molecular target information


    Molecular name: Gzmk, granzyme K

    Alias:

    • NK-Tryp-2
    • NK-tryptase-2
    • RNK-Tryp-2

    Gene sequence:NCBI_Gene: 29165

    Protein sequence:


    Rat Gzmk target molecular function (prediction)


    Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Orthologous to human GZMK (granzyme K).