PA2GX_MOUSE Q9QXX3
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UniProt:Q9QXX3
Recommended name：Group 10 secretory phospholipase A2
EC number：EC 3.1.1.4
Alternative names：(Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10)
Cleaved into：
GeneID：26565
Gene names (primary )：Pla2g10
Gene names (synonym )：
Gene names (ORF )：
Length：151
Mass：17005
Sequence：MLLLLLLLLLGPGPGFSEATRRSHVYKRGLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPRDAIDWCCYHHDCCYSRAQDAGCSPKLDRYPWKCMDHHILCGPAENKCQELLCRCDEELAYCLAGTEYHLKYLFFPSILCEKDSPKCN
Tissue specificity：Expressed at high levels in testis and the gastrointestinal tract including stomach and colon. Expressed at lower levels in other tissues including small intestine, uterus, oviduct, lung, thymus, spleen and brain (PubMed:11019817, PubMed:21266581). Expressed in Paneth-like secretory epithelial cells of the colon (PubMed:27292189). Expressed in gastric and ileac epithelial cells and in glandular epithelium of intestinal mucosa (at protein level) (PubMed:21266581). Expressed in late spermatogenic cells, spermatocytes and spermatids, but not spermatogonia in seminiferous tubules (at protein level) (PubMed:20424324). Expressed mainly in the apical side of endometrial epithelial cells and in the interstitium beneath the epithelium of uterus (at protein level) (PubMed:21266581). Expressed in resident spleen macrophages (at protein level) (PubMed:11019817). Expressed at outermost layer of hair follicles (PubMed:21266583). Expressed in dorsal root ganglia in both NEFH-positive A-fibers and PRPH-positive C-fibers (at protein level) (PubMed:21266581). {ECO:0000269|PubMed:11019817, ECO:0000269|PubMed:20424324, ECO:0000269|PubMed:21266581, ECO:0000269|PubMed:21266583, ECO:0000269|PubMed:27292189}.
Induction：Up-regulated in alveolar macrophages upon allergen-induced airway inflammation (PubMed:17403936). Up-regulated in bronchoalveolar lavage fluid (BALF) in response to house dust mite proteolytic allergens (PubMed:29093264). {ECO:0000269|PubMed:17403936, ECO:0000269|PubMed:29093264}.
Developmental stage：During hair follicle growth cycle, it is detected at low levels at 17.5 dpc (hair folliculogenesis stage), increases to a maximum expression level by P10 (anagen), declines to the basal level at P15-20 (catagen to telogen), and again increases at P25 (re-entry into the next anagen). {ECO:0000269|PubMed:21266583}.
Protein families：Phospholipase A2 family