KCNKI_MOUSE Q6VV64
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UniProt:Q6VV64
Recommended name：Potassium channel subfamily K member 18
EC number：
Alternative names：(Two-pore-domain potassium channel TRESK)
Cleaved into：
GeneID：332396
Gene names (primary )：Kcnk18
Gene names (synonym )：Tresk-2 Tresk2
Gene names (ORF )：
Length：394
Mass：44403
Sequence：MEAEEPPEARRCCPEALGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDDLCNILKCNLTVVEGSRKNLCEHLQHLKPQWLKAPQDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILATILSRAYSRFQALLCLPHDIFKWRSLPLCRKQPDSKPVEEAIPQIVIDAGVDELLNPQPSKDPPSPSCNVELFERLVAREKKNKLQPPTRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVVFAYISCAAAILPFWETELGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYKTLMLFVCQREVSLPW
Tissue specificity：Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis. High expression in trigeminal ganglion, also expressed in autonomic nervous system ganglia such as the stellate ganglion and paravertebral sympathetic ganglia. Expressed in all adult spinal cord and brain regions, with slightly higher expression in thalamus, hypothalamus, hippocampus and posterior corte (at protein level). In non-neuronal tissues, substantial expression found in lung and heart and weal expression in liver, testis, kidney, small intestine and spleen. {ECO:0000269|PubMed:14981085, ECO:0000269|PubMed:16192517, ECO:0000269|PubMed:17962323, ECO:0000269|PubMed:20871611}.
Induction：
Developmental stage：Expression appears in trigeminal ganglion and dorsal root ganglia from 15.5 dpc and increased through 18 dpc to reach a peak in newborn mouse postnatal day 1. {ECO:0000269|PubMed:20871611}.
Protein families：Two pore domain potassium channel (TC 1.A.1.8) family