CP2CN_MOUSE E9Q5K4
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UniProt:E9Q5K4
Recommended name：Cytochrome P450 2C44
EC number：EC 1.14.14.-
Alternative names：(Arachidonic acid epoxygenase)
Cleaved into：
GeneID：226143
Gene names (primary )：Cyp2c23
Gene names (synonym )：Cyp2c44
Gene names (ORF )：
Length：494
Mass：56422
Sequence：MELLGLPTLALLVLVMSLSLLSVWTKMRTGGRLPPGPTPLPIIGNILQLDLKDIPASLSKLAKEYGPVYTLYFGSWPTVVLHGYDVVKEALLNQGDEFLGRGPLPIIEDSQKGHGIVFSEGERWKLLRRFSLMTLKNFGMGKRSLEERVQEEARCLVEELHKTEAQPFDPTFILACAPCNVICSILFNERFPYNDKTFLNLMDLLNKNFYQLNSIWIQMYNLWPTIMKYIPGKHREFSKRLGGVKNFILEKVKEHQESLDPANPRDYIDCFLSKIEEEKHNLKSDFNLENLAICGSNLFTAGTETTSTTLRFGLLLLVKHPEVQAKVHEELDRVIGRHQPPSMKDKMKLPYTDAVLHEIQRYITLLPSSLPHAVVQDTKFRHYVIPKGTAVFPFLSSILLDQKEFPNPEKFDPGHFLDKNGCFKKTDYFVPFSLGKRSCVGEGLARMELFLFFTTILQKFSLKALVEPKDLDIKPVTTGLFNLPPPYKLRLVPR
Tissue specificity：Highly expressed in liver, particularly in hepatocytes and bile duct epithelial cells (at protein level) (PubMed:24966089). Expressed in nephron segments (PubMed:24966089, PubMed:15084647). Prominent expression is detected in proximal tubules at the corticomedullary junction (at protein level) (PubMed:15084647). Also expressed in renal cortical collecting duct (PubMed:15084647). Lower expression levels are detected in adrenal glands (PubMed:15084647). {ECO:0000269|PubMed:15084647, ECO:0000269|PubMed:24966089}.
Induction：Up-regulated by high sodium or high potassium diets. High sodium intake increases expression in thick ascending limb and distal convoluted tubule. An increase in dietary potassium intake induces expression in distal convoluted tubule and cortical collecting duct. {ECO:0000269|PubMed:24966089}.
Developmental stage：
Protein families：Cytochrome P450 family