E2AK1_MOUSE Q9Z2R9
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UniProt:Q9Z2R9
Recommended name：Eukaryotic translation initiation factor 2-alpha kinase 1
EC number：EC 2.7.11.1
Alternative names：(Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Hemin-sensitive initiation factor 2-alpha kinase)
Cleaved into：
GeneID：15467
Gene names (primary )：Eif2ak1
Gene names (synonym )：Hri
Gene names (ORF )：
Length：619
Mass：69702
Sequence：MLGGSSVDGERDTDDDAAGAVAAPPAIDFPAEVSDPKYDESDVPAELQVLKEPLQQPTFPFLVANQLLLVSLLEHLSHVHEPNPLHSKQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCQDNSYMQKIRSREIAFEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQGGVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLVVRNSSESESSIELQEDGLTDLSVRPVVRHQLPLGHSSELEGNFTSTDESSEGNLNLLGQTEVRYHLMLHIQMQLCELSLWDWITERNKRSREYVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACADIIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLEGSQYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQLLQSELFQTTGNVNLTLQMKIIEQEKEIEELKKQLSLLSQDRGLKR
Tissue specificity：Expressed predominantly in erythroid cells, mature reticulocytes, as well as fetal liver nucleated erythroid cells (PubMed:11689689). At much lower levels, expressed in hepatocytes and bone marrow-derived macrophages (at protein level) (PubMed:17932563, PubMed:20071449). {ECO:0000269|PubMed:11689689, ECO:0000269|PubMed:17932563, ECO:0000269|PubMed:20071449}.
Induction：By phenobarbital. {ECO:0000269|PubMed:16893190}.
Developmental stage：Highly expressed in fetal liver erythroid precursor cells at 14.5 dpc (at protein level). {ECO:0000269|PubMed:17932563}.
Protein families：Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily