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IL7R molecular target information overview


  • Molecular name: IL7R, interleukin 7 receptor
  • Gene family: CD molecules; Fibronectin type III domain containing; Interleukin receptors
  • Alias: CD127; IL7RA


    • Overview of IL7R molecular targets


    CD127 is the alpha chain of the interleukin 7 receptor, and together with CD132 (beta chain) forms a high-affinity receptor. CD127 is expressed in most T cells, but can be reduced after T cell activation. It is also expressed in B cell precursors and monocytes. The expression of CD127 plays an important role in the maturation, maintenance and immune response of T lymphocytes.


    Human IL7R Molecular Target Information


    Molecular name: IL7R, interleukin 7 receptor


    Alias:

    • CD127
    • CD127 antigen
    • CDW127
    • IL-7 receptor subunit alpha
    • IL-7R subunit alpha
    • IL-7R-alpha
    • IL-7RA
    • IL7RA
    • ILRA
    • interleukin 7 receptor alpha chain
    • interleukin 7 receptor isoform H5-6
    • interleukin-7 receptor subunit alpha

    Gene sequence:NCBI_Gene: 3575

    Protein sequence:UniProtKB: P16871


    Human IL7R target molecular function (prediction)


    Enables cytokine receptor activity. Involved in positive regulation of cell population proliferation and positive regulation of receptor signaling pathway via STAT. Located in cytosol; nucleoplasm; and plasma membrane. Implicated in severe combined immunodeficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.


    Mouse Il7r molecular target information


    Molecular name: Il7r, interleukin 7 receptor


    Alternate names:

    • CD127
    • IL-7 receptor alpha chain
    • IL-7Ralpha


    Gene sequence:NCBI_Gene: 16197

    Protein sequence:


    Mouse Il7r target molecular function (prediction)


    Predicted to enable cytokine receptor activity. Involved in defense response to Gram-positive bacterium. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of T cell mediated cytotoxicity; and positive regulation of T cell differentiation in thymus. Located in external side of plasma membrane. Is expressed in adrenal gland; brain; early conceptus; hemolymphoid system; and lymphatic system. Human ortholog(s) of this gene implicated in severe combined immunodeficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human IL7R (interleukin 7 receptor).


    Rat Il7r molecular target information


    Molecular name: Il7r, interleukin 7 receptor

    Alias:

    • LOC294797
    • interleukin-7 receptor subunit alpha

    Gene sequence:NCBI_Gene: 294797

    Protein sequence:UniProtKB: D4A3X8


    Rat Il7r target molecular function (prediction)


    ENCODES a protein that exhibits cytokine receptor activity (ortholog); INVOLVED IN B cell proliferation (ortholog); cell morphogenesis (ortholog); defense response to Gram-positive bacterium (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; COVID-19 (ortholog); endometriosis (ortholog); FOUND IN cytosol (ortholog); external side of plasma membrane (ortholog); nucleoplasm (ortholog);