CD8A molecular target information overview
CD8A molecular target review
CD8, also known as T8 or Leu2, is a member of the immunoglobulin superfamily and is expressed in most thymocytes, peripheral blood T cell subsets, and NK cells (basically CD8α/α homodimers). CD8 plays an important role in antigen recognition and T cell activation as a T cell receptor restricted by MHC class I molecules and in thymic differentiation.
Human CD8A Molecular Target Information
Molecular name: CD8A, CD8a molecule
Alias:
- CD8
- cd8 antigen, alpha chain
- CD8 antigen, alpha polypeptide (p32)
- Cluster of Differentiation 8a
- Leu2
- Leu2 T-lymphocyte antigen
- MAL
- OKT8 T-cell antigen
- p32
- T cell co-receptor
- T-cell antigen Leu2
- T-cell surface glycoprotein CD8 alpha chain
- T-lymphocyte differentiation antigen T8/Leu-2
- T8 T-cell antigen
Gene sequence:NCBI_Gene: 925
Protein sequence:UniProtKB: P01732
Human CD8A target molecule function (prediction)
Enables MHC class I protein complex binding activity. Predicted to be involved in T cell mediated immunity; cell surface receptor signaling pathway; and cytotoxic T cell differentiation. Predicted to act upstream of or within defense response to virus and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane and plasma membrane raft. Biomarker of COVID-19; erythema multiforme; and stomach cancer.
Mouse Cd8a molecular target information
Molecular name: Cd8a, CD8 antigen, alpha chain
Alias:
- BB154331
- expressed sequence BB154331
- Ly-2
- Ly-35
- Ly-B
- lymphocyte antigen 2
- lymphocyte antigen 35
- Lyt-2
- T-lymphocyte antigen 2
Gene sequence:NCBI_Gene: 12525
Protein sequence:
- UniprotKB: P01731
- UniprotKB: Q3UUV7
- UniprotKB: Q542K6
- UniprotKB: Q60965
- UniprotKB: Q8C2L1
- UniprotKB: Q8C2Q0
- UniprotKB: Q8CAX3
- UniprotKB: Q8K2M2
Mouse Mouse Cd8a Target Molecular Function (Prediction)
Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule).
Rat Cd8a molecular target information
Molecular name: Cd8a, CD8a molecule
Alias:
- CD8 antigen 32 kDa chain
- CD8 antigen alpha-chain
- CD8 antigen, alpha chain
- CD8 antigen, alpha-chain
- OX-8 membrane antigen
- T-cell surface glycoprotein CD8 alpha chain
Gene sequence:NCBI_Gene: 24930
Protein sequence:UniProtKB: P07725
Rat Cd8a target molecular function (prediction)
Enables protein kinase binding activity. Involved in T cell activation. Predicted to be located in cell surface and plasma membrane raft. Predicted to be active in external side of plasma membrane. Orthologous to human CD8A (CD8a molecule).