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IL3RA molecular target information overview


  • Molecular name:IL3RA, interleukin 3 receptor subunit alpha
  • Gene family:CD molecules;


    Overview of IL3RA molecular targets


    CD123 is a 70 kD transmembrane molecule that belongs to the α chain of the IL-3 receptor. CD123 can bind to IL-3 with low affinity alone, but if it is linked to CDw131 (β chain), it can bind to IL-3 with high affinity. CD123 alone will not transmit intracellular signals when bound to IL-3, and requires the assistance of the β chain. CD123 is usually expressed in myeloid precursor cells, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.


    Human IL3RA Molecular Target Information


    Molecular name:IL3RA, interleukin 3 receptor subunit alpha


    Alias:

    • CD123
    • CD123 antigen
    • hIL-3Ra
    • IL-3 receptor alpha SP2 isoform
    • IL-3 receptor subunit alpha
    • IL-3R subunit alpha
    • IL-3R-alpha
    • IL-3RA
    • IL3R
    • IL3RAY
    • IL3RX
    • IL3RY
    • interleukin 3 receptor, alpha (low affinity)
    • interleukin-3 receptor subunit alpha
    • MGC34174

    Gene sequence:NCBI_Gene: 3563

    Protein sequence:UniProtKB: P26951


    Human IL3RA target molecular function (prediction)


    Predicted to enable cytokine receptor activity and interleukin-3 binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane.


    Mouse Il3ra molecular target information


    Molecular name: Il3ra, interleukin 3 receptor, alpha chain


    Also known as:

    • CD123
    • IL-3 receptor alpha chain
    • SUT-1


    Gene sequence:NCBI_Gene: 16188

    Protein sequence:


    Mouse Il3ra target molecular function (prediction)


    Enables interleukin-3 binding activity and interleukin-3 receptor activity. Acts upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Located in membrane. Is expressed in several structures, including cardiovascular system mesenchyme; dorsal aorta; early conceptus; genitourinary system;


    Rat Il3ra molecular target information


    Molecular name:Il3ra, interleukin 3 receptor subunit alpha

    Alias:

    • Cyrl
    • cytokine receptor-like protein CYRL
    • interleukin 3 receptor, alpha
    • interleukin 3 receptor, alpha chain
    • interleukin-3 receptor subunit alpha

    Gene sequence:NCBI_Gene: 246144

    Protein sequence:UniProtKB: E9PSX4


    Rat Il3ra target molecular function (prediction)


    Predicted to enable interleukin-3 binding activity and interleukin-3 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within interleukin-3-mediated signaling pathway; monocyte differentiation; and regulation of cell growth. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha).