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XPNPEP2 molecular target information overview


  • Molecular name: XPNPEP2, X-prolyl aminopeptidase 2
  • Gene family: Aminopeptidases; M24 metallopeptidase family
  • Alias: X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; Xaa-Pro aminopeptidase 2


    • XPNPEP2 molecular targets review


    Membrane-bound X-prolyl aminopeptidase 2, also known as XPNPEP2, belongs to the M24B peptidase family. XPNPEP2 has been reported to be associated with aminopeptidase P (APP) activity. The C-2399A variant of XPNPEP2 is associated with reduced APP activity and increased incidence of AE-ACEi. APP is a specific hydrolase of N-terminal imide bonds, which are common in some collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. The membrane-bound and soluble forms of XPNPEP2 have been identified as 2 separate gene products. Translocation disrupts XPNPEP2, which encodes a Xaa proline aminopeptidase that hydrolyzes N-terminal Xaa-proline bonds. XPNPEP2 mRNA is detectable in translocated fibroblasts, suggesting that the gene can at least partially escape X chromosome inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).


    Human XPNPEP2 Molecular Target Information


    Molecular name: XPNPEP2, X-prolyl aminopeptidase 2


    Alias:

    • AEACEI
    • aminoacylproline aminopeptidase
    • APP2
    • mAmP
    • membrane-bound aminopeptidase P
    • membrane-bound AmP
    • membrane-bound APP
    • X-Pro aminopeptidase 2
    • X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    • xaa-Pro aminopeptidase 2

    Gene sequence:NCBI_Gene: 7512

    Protein sequence:UniProtKB: O43895


    Human XPNPEP2 target molecular function (prediction)


    Predicted to enable aminopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. Implicated in acquired angioedema.


    Mouse Mouse Xpnpep2 molecular target information


    Molecular name: Xpnpep2, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound


    Alternate name:

    • 9030008G12Rik
    • mAPP
    • RIKEN cDNA 9030008G12 gene


    Gene sequence:NCBI_Gene: 170745

    Protein sequence:


    Mouse Xpnpep2 target molecular function (prediction)


    Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular exosome. Is expressed in brain; forelimb bud; large intestine; and neural retina. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2).


    Rat Xpnpep2 molecular target information


    Molecular name: Xpnpep2, X-prolyl aminopeptidase 2

    Alias:

    • LOC102551432
    • mAPP
    • membrane-bound aminopeptidase P
    • membrane-bound APP
    • X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    • xaa-Pro aminopeptidase 2
    • xaa-Pro aminopeptidase 2-like

    Gene sequence:NCBI_Gene: 117522

    Protein sequence:UniProtKB: Q99MA2


    Rat Xpnpep2 target molecular function (prediction)


    Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular exosome. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2).