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Overview of IL2 molecular targets

Interleukin 2 (IL-2) is a 15 kDa glycoprotein that, in humans, is encoded by a single gene located in the q26–28 region of chromosome 4. It is a signaling molecule in the immune system that regulates the activity of white blood cells (leukocytes, usually lymphocytes) that have immune functions. IL-2 is the body's natural response to microbial infection, distinguishing between foreign and self antigens. IL-2 functions by binding to the IL-2 receptor, which consists of three chains: the alpha chain (CD25), the beta chain (CD122), and the gamma chain (CD132). Monitoring IL-2 levels in serum provides a more detailed view of a variety of pathological conditions, including cancer, infectious diseases, transplant rejection, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.

Human IL2 Molecular Target Information

Molecular name: IL2, interleukin 2

Alias:

• aldesleukin
• IL-2
• interleukin-2
• involved in regulation of T-cell clonal expansion
• lymphokine
• T cell growth factor
• TCGF

Gene sequence:NCBI_Gene: 3558

Protein sequence: UniProtKB: P60568

Human IL2 target molecular function (prediction)

Acts upstream of or within negative regulation of B cell apoptotic process; positive regulation of B cell proliferation; and positive regulation of activated T cell proliferation. Predicted to be located in extracellular space. Implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including Zellweger syndrome; aggressive periodontitis; anogenital venereal wart; autoimmune disease (multiple); and uveitis (multiple).

Mouse Il2 molecular target information

Molecular name: Il2, interleukin 2

Alias:

• IL-2
• Il-2

Gene sequence:NCBI_Gene: 16183

Protein sequence:

• UniprotKB: P04351
• UniprotKB: P70291
• UniprotKB: P70292
• UniprotKB: P70293
• UniprotKB: P70294
• UniprotKB: Q0PGS4
• UniprotKB: Q546X1
• UniprotKB: Q8BHA4
• UniprotKB: Q91Y49
• UniprotKB: Q9QUS8

Mouse Il2 target molecular function (prediction)

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).

Rat Il2 molecular target information

Molecular name: Il2, interleukin 2

Alias:

• IL-2
• interleukin-2
• T-cell growth factor
• TCGF

Gene sequence:NCBI_Gene: 116562

Protein sequence:UniProtKB: P17108

Rat Il2 target molecular function (prediction)

Enables carbohydrate binding activity; glycosphingolipid binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of T cell activation; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of protein phosphorylation. Located in extracellular space. Used to study cystitis. Biomarker of allergic rhinitis; colorectal carcinoma; and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2).