KNDC1_MOUSE Q0KK55
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UniProt:Q0KK55
Recommended name：Kinase non-catalytic C-lobe domain-containing protein 1
EC number：
Alternative names：(KIND domain-containing protein 1) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2)
Cleaved into：
GeneID：76484
Gene names (primary )：Kndc1
Gene names (synonym )：Kiaa1768 Rasgef2 Vkind
Gene names (ORF )：
Length：1742
Mass：191313
Sequence：MQAMDPASRGFYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQTLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDLTGNTFEAHIYSLGATLKAALEYVPEPELEPKLSTDLEGLLSQMQAEDPRERPDLASIIALCEEKMQPVSSCRLCRSLSAIGRRVLSIESFGAFQELSENTWRGRPAPRNVGPKKMPGDLSTDPEALFPSKGLLQPPASRDAEQEAGQRPRAPSPKPLLSAPVRNGENPGQEGLADLVLDARCPLGELDRDNLRRSRLKKAQTFPRLLQESTETSTLCLSLNGSRNQLAISEFFPPDPRKLFLEGKNGLSGFKTQSKSRLWPEQEPGVQLDKTPGAGRNPHRSPGASGQLEASSPSQGSVEYKPSPSPVDAGDSDHEGHIPRSEEKIPEESRQPGSTATEQSLSLKDLLSKLGRPFREYELWALCLSCLSTLQTHKEHPAHLCLDNVLVAEDGTVFFGPPPANGAYNSLFLAPEVSEEKLVTEKASVYCVAAVLWTAAKFSVPRDHKLALPRRLKTLLLDMARRHASERPSAAEAIKVCSSYLLQRGMDSSKILAHLRASTCKVHPEEETIGLQNAFSVVELKSTTAPAPESSPGFLQVSNDTKLVAVPGPVPGLPPCCKEACELPAAFTSEATHFKPIVLAQDASVTRDQLALPSESNEKPKEGSGHLDREGTRKQAALELVEATDLKMSNQLSPGPELQGATPDPDGDSGSPSSATECSCPHGPALVTQQKGTSGTPSSPASSLPPEHRPDGEGPLGTTVLPGPTSASQGSRHPCKPPRGKAAASPSSPRGSDGHPEKPRPADRKLCPSSVDTSSPPKMTACPSLQEAMRLIQEEFAFDGYMDNGLEALIMGEYIYALKDLTFATFCGAISEKFCDLYWDEQLLKNLFKVVNGPASPSESTSEEPGSQPEHSPSRCSLSSKRPSLHGLGKEKPATTWGSGGPCSPTALSDIDSDTLSQGNFEVGFRSQKSIKVTREQQPEAEVGGQPGPSQDSTSHASDTVARLARSEDGGPAGSPGASDFQNCSPGWSSAFYEADCFGADVYNYVKDLERQKTNGHTELEAQSPELEQQLMIEKRNYRKTLKFYQKLLQKEKRNKGSEVRTMLSKLRGQLDEMKSKVQFLSLVKKYLQVMYAERWGLEPCALPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGSGRQKKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRISSTLSRAHQDPTSTFTKIYRRSLCVLQAWVEDCYTVDFIRNAGLLGQLEDFISSKILPLDGTAEHLLALLEVGTERRADSASRGADLEDPKEAEEDTRPFNALCKRFSEDGITRKSFSWRLPRGNGLVLPHHKERQYTIASALPKPCFFEDFYGPYAKASEKGPYFLTEYSTNQLFTQLTLLQQELFQKCHPVHFLNSRALGVMDKSAAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILGGLEHLAVRQSPAWRILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVASQVHAFQENPYTFSPDPKLQAHLKQRIARFSGADVSILAADNRANFHQIPGEKHSRKIQDKLRRMKATFQ
Tissue specificity：Highly expressed in the brain and at low levels in the ovary. In the brain it is most prominently expressed in the cerebellum where it is restricted to the granular Purkinje cell layer. {ECO:0000269|PubMed:16099729, ECO:0000269|PubMed:17984326}.
Induction：
Developmental stage：At 14.5 dpc, highly expressed in the mid- and hindbrain and only weakly in the forebrain, but during development the main expression shifts towards the telencephalon as seen at 17.5 dpc (PubMed:16099729). In cerebellum expression is highly up-regulated between postnatal days P7 and P12. At P7, low expression levels throughout the brain, but high in hippocampus, thalamus and the cerebellar white matter (PubMed:17984326). {ECO:0000269|PubMed:16099729, ECO:0000269|PubMed:17984326}.
Protein families：