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IGFBP6 molecular target information overview


  • Molecular name: IGFBP6, insulin like growth factor binding protein 6
  • Gene family: Insulin like growth factor binding proteins
  • Alias: insulin-like growth factor binding protein 6


    • Review of IGFBP6 molecular targets


    The insulin-like growth factor (IGF) binding protein superfamily includes six high-affinity IGF binding proteins (IGFBPs) and at least four low-affinity binding proteins called IGFBP-related proteins (IGFBP-rPs). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues. IGFBPs contribute to the extended half-life of IGFs in all tissues, including the prostate. In humans, insulin-like growth factor binding protein 6 (IGFBP-6) is a protein encoded by the IGFBP6 gene. IGFBP-6 binds IGF-II with higher affinity than IGF-I, and it is a specific inhibitor of IGF-II. IGFBP-6 is reported to play a role in cell proliferation, survival, differentiation, and migration independently of IGF. IGFBP-6 is unique among IGFBPs due to its distinct IGF-II binding preference.


    Human IGFBP6 Molecular Target Information


    Molecular name:IGFBP6, insulin like growth factor binding protein 6


    Alias:

    • IBP-6
    • IBP6
    • IGF binding protein 6
    • IGF-binding protein 6
    • IGFBP-6
    • insulin-like growth factor binding protein 6
    • insulin-like growth factor-binding protein 6

    Gene sequence:NCBI_Gene: 3489

    Protein sequence:UniProtKB: P24592


    Human IGFBP6 target molecular function (prediction)


    Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy.


    Mouse Igfbp6 molecular target information


    Molecular name:Igfbp6, insulin-like growth factor binding protein 6


    Alias:

    • IGFBP-6


    Gene sequence:NCBI_Gene: 16012

    Protein sequence:


    Mouse Igfbp6 target molecular function (prediction)


    Predicted to enable fibronectin binding activity; identical protein binding activity; and insulin-like growth factor binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and of insulin-like growth factor regulation regulation signaling pathway. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including blastocyst; compacted morula; genitourinary system; liver; and spleen. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6).


    Rat Igfbp6 molecular target information


    Molecular name:Igfbp6, insulin-like growth factor binding protein 6

    Alias:

    • IBP-6
    • IGF-binding protein 6
    • IGF-BP6
    • IGFBP-6
    • insulin-like growth factor-binding protein 6
    • RBP6A
    • RBP6G

    Gene sequence:NCBI_Gene: 25641

    Protein sequence:UniProtKB: P35572


    Rat Igfbp6 target molecular function (prediction)


    Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus and extracellular space. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6).