ITGAM molecular target information overview
ITGAM molecular target review
CD11b binds to CD18 non-covalently to form αM-β2 integrin (Mac-1), which binds to CD54 (ICAM-1), C3bi and fibrinogen. Mac-1 is expressed on macrophages, NK cells, granulocytes, microglia, activated lymphocytes and mouse B-1 cells. CD11b binds to its ligand and participates in the interaction of adhesion cells. This antibody can also cross-recognize human CD11b and can detect this antigen on monocytes, granulocytes and a certain group of NK cells in human peripheral blood.
Human ITGAM Molecular Target Information
Molecular name: ITGAM, integrin subunit alpha M
Alias:
- antigen CD11b (p170)
- CD11 antigen-like family member B
- CD11B
- cell surface glycoprotein MAC-1 subunit alpha
- complement component 3 receptor 3 subunit
- CR-3 alpha chain
- CR3A
- integrin alpha-M
- integrin, alpha M (complement component 3 receptor 3 subunit)
- integrin, alpha M (complement component receptor 3, alpha)
- leukocyte adhesion receptor MO1
- MAC-1
- MAC1A
- macrophage antigen alpha polypeptide
- macrophage-1 antigen alpha subunit
- MGC117044
- MO1A
- neutrophil adherence receptor alpha-M subunit
- SLEB6
Gene sequence:NCBI_Gene: 3684
Protein sequence: UniProtKB: P11215
Human ITGAM target molecular function (prediction)
Enables heat shock protein binding activity. Involved in ectodermal cell differentiation; positive regulation of neutrophil degranulation; and positive regulation of superoxide anion generation. Located in cell surface; extracellular space; and plasma membrane raft. Implicated in lupus nephritis.
Mouse Itgam molecular target information
Molecular name: Itgam, integrin alpha M
Alias:
- Cd11b
- CD11B (p170)
- CD11b/CD18
- complement component receptor 3 alpha
- complement receptor type 3
- CR3
- F730045J24Rik
- Ly-40
- lymphocyte antigen 40
- Mac-1
- Mac-1 alpha
- Mac-1a
- macrophage antigen alpha chain (integrin)
- RIKEN cDNA F730045J24 gene
Gene sequence:NCBI_Gene: 16409
Protein sequence:
Mouse Itgam target molecular function (prediction)
Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).
Rat Itgam molecular target information
Molecular name: Itgam, integrin subunit alpha M
Alias:
- Cd11b
- integrin alpha M
- Integrin alpha-M
- integrin, alpha M
Gene sequence:NCBI_Gene: 25021
Protein sequence:
Rat Itgam target molecular function (prediction)
Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to contribute to cargo receptor activity. Predicted to be involved in several processes, including endocytosis; positive regulation of myeloid leukocyte mediated immunity; and positive regulation of neuron death. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular space; and plasma membrane raft. Predicted to be integral component of membrane. Predicted to be part of integrin alphaM-beta2 complex. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).