CDH1 Molecular Target Information Overview
Overview of CDH1 Molecular Targets
CDH1, also known as E-cadherin and CD324, is a calcium-dependent cell adhesion molecule. It consists of five repeats of cadherin in the extracellular domain, a transmembrane domain, and an intracellular domain that binds p120-catenin and β-catenin. CDH1 in adult tissues is expressed in epithelial tissues, where it is constantly regenerated and has a half-life of 5 hours on the cell surface. Loss of CDH1 function or expression is associated with tumor progression and metastasis. Downregulation of CDH1 expression can reduce the adhesion strength of cells in tissues, leading to increased cell motility. In turn, it allows cancer cells to pass through the basement membrane and infiltrate surrounding tissues. Pathologists often use CDH1 to diagnose different types of breast cancer. Immunohistochemical studies have shown that CDH1 expression is significantly reduced or mostly absent in invasive lobular carcinoma compared with invasive ductal carcinoma.
Human CDH1 Molecular Target Information
Molecular name: CDH1, cadherin 1
Synonyms:
- Arc-1
- BCDS1
- cadherin 1, E-cadherin (epithelial)
- cadherin 1, type 1
- cadherin 1, type 1, E-cadherin (epithelial)
- cadherin-1
- calcium-dependent adhesion protein, epithelial
- CAM 120/80
- CD324
- CDHE
- cell-CAM 120/80
- E-Cadherin
- E-cadherin 1
- ECAD
- epithelial cadherin
- LCAM
- UVO
- uvomorulin
Gene sequence:NCBI_Gene: 999
Protein sequence:UniProtKB: P12830
Human CDH1 target molecular function (prediction)
Enables several functions, including GTPase activating protein binding activity; ankyrin binding activity; and beta-catenin binding activity. Involved in several processes, including cellular response to indole-3-methanol; cellular response to lithium ion; and positive regulation of protein import into nucleus. Located in several cellular components, including adherens junction; lateral plasma membrane; and trans-Golgi network. Is integral component of membrane. Part of catenin complex and flotillin complex. Colocalizes with cortical actin cytoskeleton. Implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). fibrosis.
Mouse Cdh1 molecular target information
Molecular name: Cdh1, cadherin 1
Alias:
- AA960649
- E-cad
- E-cadherin
- Ecad
- expressed sequence AA960649
- L-CAM
- Um
- UM
- uvomorulin
Gene sequence:NCBI_Gene: 12550
Protein sequence:
Mouse Cdh1 target molecular function (prediction)
Acts upstream of or within several processes, including bicellular tight junction assembly; epithelial cell development; and regulation of proteolysis. Located in several cellular components, including Schmidt-Lanterman incisure; axon; and basolateral plasma membrane. Part of catenin complex and flotillin complex. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).
Rat Cdh1 molecular target information
Molecular name: Cdh1, cadherin 1
Alias:
- cadherin-1
- E-cadherin
- epithelial cadherin
- uvomorulin
Gene sequence:NCBI_Gene: 83502
Protein sequence:UniProtKB: Q9R0T4
Rat Cdh1 target molecular function (prediction)
Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).