CHIA_MOUSE Q91XA9
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UniProt:Q91XA9
Recommended name：Acidic mammalian chitinase
EC number：EC 3.2.1.14
Alternative names：(AMCase) (YNL)
Cleaved into：
GeneID：81600
Gene names (primary )：Chia
Gene names (synonym )：Chia1
Gene names (ORF )：
Length：473
Mass：52003
Sequence：MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
Tissue specificity：Detected in macrophages and lung epithelial cells. Detected in the acinar cells of parotid gland and von Ebner's gland but not in submandibular and sublingual glands. Detected in gastric chief cells. Also present in parotid glandular saliva and gastric juice (at protein level). Highly expressed in submandibular gland (PubMed:11085997) and stomach. Highly expressed in parotid gland but not in submandibular and sublingual glands (PubMed:12133911). In tongue, expressed only in von Ebner's gland. Expressed at lower levels in lung. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:12133911, ECO:0000269|PubMed:12971947, ECO:0000269|PubMed:15192232, ECO:0000269|PubMed:18824549}.
Induction：Up-regulated upon pulmonary inflammation elicited by sensitization and aerosol challenge with the aeroallergen ovalbumin. Up-regulated during T-helper cell type 2 (Th2) inflammation. Induction is mediated by IL-13. {ECO:0000269|PubMed:15192232}.
Developmental stage：In parotid gland, weak expression detected at postnatal day P12, with levels increasing towards P16. In stomach, first detected at P16, with expression reaching adult levels during P20-24. {ECO:0000269|PubMed:12133911}.
Protein families：Glycosyl hydrolase 18 family, Chitinase class II subfamily