Overview of TF molecular target information
Overview of TF molecular targets
Transferrin (TF) is a secretory protein belonging to the transferrin family. It is expressed by the liver and secreted into the plasma. TF has a molecular weight of approximately 80 kDa and contains two specific high-affinity Fe3+ binding sites. TFs are iron-binding glycoproteins present in plasma that regulate the level of free iron in biological fluids. Its main function is to transport iron from the duodenal absorption center and leukocyte macrophages to other tissues. TF is associated with the innate immune system. Its levels are reduced in inflammatory conditions. We often see increased plasma TF levels in patients with iron deficiency anemia. Plasma TF levels are usually reduced in patients with iron overload and protein malnutrition. Recently, it has been found that TF and its receptor can reduce tumor cells when antibodies are attracted to the TF receptor. TF is an acute phase protein, so its levels are reduced in inflammation, cancer and certain diseases.
Human TF molecular target information
Molecular name: TF, transferrin
Alias:
- beta-1 metal-binding globulin
- DKFZp781D0156
- epididymis secretory sperm binding protein Li 71p
- HEL-S-71p
- PRO1557
- PRO2086
- serotransferrin
- siderophilin
- TFQTL1
Gene sequence:NCBI_Gene: 7018
Protein sequence:UniProtKB: P02787
Human TF target molecular function (prediction)
Enables ferrous iron binding activity; iron chaperone activity; and transferrin receptor binding activity. Involved in cellular response to iron ion; positive regulation of receptor-mediated endocytosis; and regulation of iron ion transport. Located in several cellular components, including basal plasma membrane; clathrin-coated pit; and cytoplasmic vesicle. Is extrinsic component of external side of plasma membrane. Part of HFE-transferrin receptor complex. Implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Biomarker of glomerulonephritis; hypertension; and membranous glomerulonephritis.
Mouse Trf molecular target information
Molecular name: Trf, transferrin
Alias:
- AI266983
- expressed sequence AI266983
- HP
- hpx
- hypotransferrinemia with hemochromatosis
- Tfn
Gene sequence:NCBI_Gene: 22041
Protein sequence:
- UniprotKB: Q921I1
- UniprotKB: D3YYR8
- UniprotKB: E9Q2Q7
- UniprotKB: E9Q939
- UniprotKB: F7BAE9
- UniprotKB: F7CJN9
Mouse Trf target molecular function (prediction)
Predicted to enable iron chaperone activity; iron ion binding activity; and transferrin receptor binding activity. Involved in several processes, including ERK1 and ERK2 cascade; osteoclast differentiation; and positive regulation of bone resorption. Acts upstream of or within SMAD protein signal transduction; iron ion transport; and response to bacterium. Located in clathrin-coated pit and cytoplasmic vesicle. Is expressed in several structures, including brain; liver; placenta; white fat; and yolk sac. Used to study atransferrinemia. Human ortholog(s) of this gene implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to human TF (transferrin).
Rat Tf molecular target information
Molecular name: Tf, transferrin
Alias:
- beta-1 metal-binding globulin
- liver regeneration-related protein LRRG03
- MGC93500
- serotransferrin
- siderophilin
- Tfn
- Trf
Gene sequence:NCBI_Gene: 24825
Protein sequence:
Rat Tf target molecular function (prediction)
Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in basement membrane; cell tip; and extracellular space. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and rest legsless syndrome. to human TF (transferrin).