HSPB1 molecular target information overview
Overview of HSPB1 molecular targets
Heat shock proteins (HSPs) are a group of highly conserved stress proteins that mainly function as molecular chaperones and participate in a variety of biological processes including heat resistance, inhibition of apoptosis, regulation of cell development and cell differentiation, and signal transduction. HSP27, also known as HSPB1, is a molecular chaperone in the small molecule heat shock protein group. It is present in many cell types, especially all types of muscle cells, and is overexpressed at different stages of cell differentiation and development. HSP27 participates in the apoptotic signaling pathway and inhibits the activation of procaspase-9. In addition, HSP27 protects actin filaments from fragmentation and can also activate proteases. HSP27 may be a potential diagnostic marker, and high levels of HSP27 are present in the serum of breast cancer patients. Phosphorylated HSP27 increases the infiltration of human prostate cancer cells, promotes cell proliferation, and inhibits Fas-induced apoptosis.
Human HSPB1 Molecular Target Information
Molecular name:HSPB1, heat shock protein family B (small) member 1
Alias:
- 28 kDa heat shock protein
- CMT2F
- DKFZp586P1322
- epididymis secretory protein Li 102
- estrogen-regulated 24 kDa protein
- heat shock 27 kDa protein
- heat shock 27kD protein 1
- heat shock protein 1 protein family B member 1 isoform
- SRP27
- stress-responsive protein 27
Gene sequence:NCBI_Gene: 3315
Protein sequence:UniProtKB: P04792
Human HSPB1 target molecular function (prediction)
Enables several functions, including protein folding chaperone; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of angiogenesis; sarcoma. Biomarker of focal segmental glomerulosclerosis and rheumatoid arthritis.
Mouse Hspb1 molecular target information
Molecular name: Hspb1, heat shock protein 1
Also known as:
- heat shock protein, 25 kDa
- Hsp25
Gene sequence:NCBI_Gene: 15507
Protein sequence:
Mouse Hspb1 target molecular function (prediction)
Enables protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within negative apoptotic signaling pathway. Located in Z disc; nucleus; and plasma regulation. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and heart. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
Rat Hspb1 molecular target information
Molecular name:Hspb1, heat shock protein family B (small) member 1
Alias:
- heat shock 27 kDa protein
- heat shock 27 kDa protein 1
- heat shock 27kDa protein 1
- heat shock protein 1
- heat shock protein B1
- heat shock protein beta-1
- HSP 27
- Hsp25
- Hsp27
Gene sequence:NCBI_Gene: 24471
Protein sequence:
Rat Hspb1 target molecular function (prediction)
Enables ubiquitin binding activity. Involved in several processes, including cellular response to butyrate; cellular response to interleukin-11; and response to ischemia. Located in several cellular components, including myofibril; perikaryon; and postsynaptic density membrane. Part of proteasome complex. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).