ANGPTL4 molecular target information overview
Overview of ANGPTL4 molecular targets
Angiopoietin-like proteins, also known as angiopoietin-related proteins, are structurally related to angiopoietin. In humans, angiopoietin-like protein 4 is a protein encoded by the ANGPTL4 gene. This gene was previously also known as ANGPTL2, HFARP, PGAR, or FIAF, but has been renamed ANGPTL4. ANGPTL4 is a member of the angiopoietin-like gene family and encodes a secreted, glycosylated protein. ANGPTL4 is highly expressed in adipose tissue. In response to hypoxia, expression is upregulated in endothelial cells and cardiomyocytes. ANGPTL4 is involved in regulating fat and glucose metabolism, and it is also involved in angiogenesis. ANGPTL4 is also expressed in hypoxic human tissues and in various cancers such as liposarcoma, hepatocellular carcinoma, and conventional renal cell carcinoma.
Human ANGPTL4 Molecular Target Information
Molecular name: ANGPTL4, angiopoietin like 4
Alias:
- angiopoietin-like 4
- angiopoietin-like protein 4
- angiopoietin-related protein 4
- ANGPTL2
- ARP4
- fasting-induced adipose factor
- FIAF
- HARP
- hepatic angiopoietin-related protein
- hepatic fibrinogen/angiopoietin-related protein
- HFARP
- NL2
- peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
- PGAR
- pp1158
- PPARG angiopoietin related protein
- TGQTL
- UNQ171
Gene sequence:NCBI_Gene: 51129
Protein sequence:UniProtKB: Q9BY76
Human ANGPTL4 target molecular function (prediction)
Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and protein unfolding. Located in extracellular space.
Mouse Angptl4 molecular target information
Molecule name: Angptl4, angiopoietin-like 4
Alias:
- BK89
- FIAF
- HFARP
- NG27
Gene sequence:NCBI_Gene: 57875
Protein sequence:
Mouse Angptl4 target molecular function (prediction)
Acts upstream of or within negative of endothelial cell apoptotic process. Located in extracellular space. Is regulation expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; integumental system; and musculature. Orthologous to human ANGPTL4 (angiopoietin like 4).
Rat Angptl4 molecular target information
Molecule name: Angptl4, angiopoietin-like 4
Alias:
- angiopoietin-like protein 4
- angiopoietin-related protein 4
- hepatic fibrinogen/angiopoietin-related protein
- HFARP
- LOC362850
Gene sequence:NCBI_Gene: 362850
Protein sequence:UniProtKB: Q6TMA8
Rat Angptl4 target molecular function (prediction)
Enables identical protein binding activity. Involved in response to hypoxia. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL4 (angiopoietin like 4).