ABI2_MOUSE P62484
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UniProt:P62484
Recommended name：Abl interactor 2
EC number：
Alternative names：(Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Cleaved into：
GeneID：329165
Gene names (primary )：Abi2
Gene names (synonym )：
Gene names (ORF )：
Length：446
Mass：49387
Sequence：MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSPDKQRALEETKAYTTQSLASVAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKVSTQNMKMGGLPRTTPPTQKPPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPGHPVQFYSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYNQNPVSDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRAYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESIMHYSE
Tissue specificity：Expresses in embryonic and adult brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus. {ECO:0000269|PubMed:10995551}.
Induction：
Developmental stage：Detected at 10 dpc in developing brain, and expression is more prominent in the neuroepithelium compared to the surrounding tissue. At 12 dpc expression is enhanced throughout the CNS and is detected along the full length of the spinal chord. At 16 dpc expression remains enhanced in the CNS, and is particularly prominent in the olfactory bulb (PubMed:10995551). Also highly expressed in dorsal root ganglia (PubMed:10995551). At 18.5 dpc is prominently expressed in the marginal zone of the cortex, an area rich in neuronal and glial cell projections (at protein level) (PubMed:15572692). Detected at 16.5 dpc in ocular lens, specifically localized where the tips of migrating secondary fibers forms adherens junctions with anterior epithelial cells (at protein level) (PubMed:15572692). {ECO:0000269|PubMed:10995551, ECO:0000269|PubMed:15572692}.
Protein families：ABI family