CNTF molecular target information overview
Overview of CNTF molecular targets
Ciliary neurotrophic factor (CNTF) is a protein encoded by the ciliary neurotrophic factor gene in humans. Human CNTF is a single-chain polypeptide with 200 amino acid (aa) residues and a molecular weight of 22.7 kDa. The protein encoded by this gene is a polypeptide hormone whose actions are limited to promoting neurotransmitter synthesis and axonal growth in certain neuronal populations in the nervous system. CNTF is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory episodes. It has been shown that CNTF is also expressed in bone surface cells and can reduce osteoblast activity.
Human CNTF molecular target information
Molecular name: CNTF, ciliary neurotrophic factor
Alternative name:
- Ciliary Neuronotrophic Factor
- HCNTF
Gene sequence:NCBI_Gene: 1270
Protein sequence:UniProtKB: P26441
Human CNTF target molecular function (prediction)
Enables growth factor activity and interleukin-6 receptor binding activity. Involved in ciliary neurotrophic factor-mediated signaling pathway; negative regulation of neuron apoptotic process; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of gene expression. Predicted to be located in extracellular region. glaucoma; multiple sclerosis; and obesity. Biomarker of keratoconus.
Mouse Cntf molecular target information
Molecular name: Cntf, ciliary neurotrophic factor
Alias:
- AI429687
- expressed sequence AI429687
Gene sequence:NCBI_Gene: 12803
Protein sequence:
Mouse Cntf target molecular function (prediction)
Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of photoreceptor cell differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of retinal cell programmed cell death. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).
Rat Cntf molecular target information
Molecular name: Cntf, ciliary neurotrophic factor
Alias:
- ciliary neurotropic factor
Gene sequence:NCBI_Gene: 25707
Protein sequence:
Rat Cntf target molecular function (prediction)
Enables ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including axon; neuronal cell body; and plasma membrane bounded cell projection cytoplasm. Used to study Huntington's disease and glaucoma. disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).