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MMP8 molecular target information overview


  • Molecular name: MMP8, matrix metallopeptidase 8
  • Gene family: M10 matrix metallopeptidases
  • Former name: CLG1
  • Alias: matrix metalloproteinase 8 (neutrophil collagenase)


    • Overview of MMP8 molecular targets


    Matrix metalloproteinase 8 (MMP-8), also known as neutrophil collagenase or PMNL collagenase, is a collagenase present in the connective tissue of most mammals. The MMP-8 protein in humans is encoded by the MMP8 gene. Various substances, such as IL-1, IL-8, TNF-α and GM-CSF, can stimulate neutrophils to release MMP-8, which is a key enzyme that initiates ECM degradation. Activated MMP-8 can cleave natural proteins such as fibronectin, cartilage proteoglycans, serpins and peptides. MMP-8 affects the metastatic behavior of breast cancer cells by preventing lymph node metastasis, emphasizing the importance of anti-target identification in drug development. MMP-8 participates in wound repair by eliminating inflammation, providing certain possibilities for the development of new strategies for treating poor wound healing.


    Human MMP8 molecular target information


    Molecular name: MMP8, matrix metallopeptidase 8


    Alias:

    • CLG1
    • collagenase 2
    • HNC
    • matrix metalloproteinase 8 (neutrophil collagenase)
    • matrix metalloproteinase-8
    • MMP-8
    • neutrophil collagenase
    • PMN leukocyte collagenase
    • PMNL collagenase
    • PMNL-CL

    Gene sequence:NCBI_Gene: 4317

    Protein sequence:UniProtKB: P22894


    Human MMP8 target molecular function (prediction)


    Enables serine-type endopeptidase activity. Involved in endodermal cell differentiation and proteolysis. Located in extracellular space. Implicated in breast cancer and carotid artery disease. Biomarker of COVID-19; aortic aneurysm (multiple); arthritis (multiple); breast cancer; and female reproductive organ cancer (multiple).


    Mouse Mmp8 molecular target information


    Molecular name: Mmp8, matrix metallopeptidase 8


    Alternate names:

    • BB138268
    • Collagenase-2
    • expressed sequence BB138268


    Gene sequence:NCBI_Gene: 17394

    Protein sequence:


    Mouse Mmp8 target molecular function (prediction)


    Predicted to enable endopeptidase activity and metal ion binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of intracellular signal transduction; and regulation of cytokine production. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hindlimb digit mesenchyme; musculature; Orthologous to human MMP8 (matrix metallopeptidase 8).


    Rat Mmp8 molecular target information


    Molecular name: Mmp8, matrix metallopeptidase 8

    Alias:

    • matrix metalloproteinase-8
    • MMP-8
    • neutrophil collagenase
    • neutrophil collagenease

    Gene sequence:NCBI_Gene: 63849

    Protein sequence:


    Rat Mmp8 target molecular function (prediction)


    Enables calcium ion binding activity; metallopeptidase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of neuroinflammatory response; positive regulation of nitric oxide biosynthetic process; and positive regulation of tumor necrosis factor production. Located in extracellular space. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8).