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Overview of TREM2 molecular target information


  • Molecular name: TREM2, triggering receptor expressed on myeloid cells 2
  • Gene family: V-set domain containing
  • Alias: TREM-2; Trem2a; Trem2b; Trem2c
  • Alias: triggering receptor expressed on myeloid cells 2a


    • Overview of TREM2 molecular targets


    Triggering receptor on myeloid cells 2 (TREM2) is a single Ig domain receptor that is expressed on macrophages and dendritic cells, but not on granulocytes or monocytes. It is most abundantly expressed in the basal ganglia, corpus callosum, medulla oblongata, and spinal cord, with microglia in the central nervous system being the predominant cell type producing TREM2. TREM2 plays a role in chronic inflammation, stimulating constitutive but non-inflammatory chemokine and cytokine production. TREM2 forms a receptor signaling complex with TYROBP to activate immune responses in macrophages and dendritic cells. It also associates with the adaptor protein DAP12 to transmit activation signals that play a role in both innate and adaptive immune responses. TREM2 signaling is also an important pathway that promotes wound healing in the colon. TREM2 mutations increase the risk of neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease.


    Human TREM2 molecular target information


    Molecular name: TREM2, triggering receptor expressed on myeloid cells 2


    Alias:

    • PLOSL2
    • TREM-2
    • Trem2a
    • Trem2b
    • Trem2c
    • triggering receptor expressed on monocytes 2
    • triggering receptor expressed on myeloid cells 2a

    Gene sequence:NCBI_Gene: 54209

    Protein sequence:UniProtKB: Q9NZC2


    Human TREM2 target molecular function (prediction)


    Acts upstream of or within with a positive effect on CXCL12-activated CXCR4 signaling pathway. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; osteoclast differentiation; and positive regulation of macromolecule metabolic process. Located in plasma membrane. Is integral component of membrane and intrinsic component of plasma membrane. Part of plasma membrane raft. Biomarker of syphilis.


    Mouse Trem2 molecular target information


    Molecular name: Trem2, triggering receptor expressed on myeloid cells 2


    Alias:

    • Trem2a
    • Trem2b
    • Trem2c
    • triggering receptor expressed on myeloid cells 2a
    • triggering receptor expressed on myeloid cells 2b
    • triggering receptor expressed on myeloid cells 2c


    Gene sequence:NCBI_Gene: 83433

    Protein sequence:


    Mouse Trem2 target molecular function (prediction)


    Acts upstream of or within with a negative effect on pyroptosis. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and social behavior. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in central nervous system; embryo mesenchyme; genitourinary system;


    Rat Trem2 molecular target information


    Molecular name: Trem2, triggering receptor expressed on myeloid cells 2

    Alias:

    • LOC301227
    • Trem2-Mia
    • Trem2-Mib

    Gene sequence:NCBI_Gene: 301227

    Protein sequence:


    Rat Trem2 target molecular function (prediction)


    Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).