CHK1_MOUSE O35280
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UniProt:O35280
Recommended name：Serine/threonine-protein kinase Chk1
EC number：EC 2.7.11.1
Alternative names：(CHK1 checkpoint homolog) (Checkpoint kinase-1)
Cleaved into：
GeneID：12649
Gene names (primary )：Chek1
Gene names (synonym )：Chk1
Gene names (ORF )：
Length：476
Mass：54381
Sequence：MAVPFVEDWDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKKEICINKMLSHENVVKFYGHRREGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVETPSARITIPDIKKDRWYNKPLNRGAKRPRATSGGMSESSSGFSKHIHSNLDFSPVNNGSSEETVKFSSSQPEPRTGLSLWDTGPSNVDKLVQGISFSQPTCPEHMLVNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETFEKLGYQWKKSCMNQVTVSTTDRRNNKLIFKINLVEMDEKILVDFRLSKGDGLEFKRHFLKIKGKLSDVVSSQKVWFPVT
Tissue specificity：Found in all adult tissues tested. Elevated expression in testis, lung and spleen. 15.5 day old embryos show ubiquitous expression with strong expression in brain, liver, kidney, pancreas, intestine, thymus and lung. {ECO:0000269|PubMed:9278511}.
Induction：
Developmental stage：In the testis, present in cells undergoing meiosis I. Not detected in peripheral cells in seminiferous tubules that are undergoing pre-meiotic DNA synthesis or in late condensing or mature sperm. {ECO:0000269|PubMed:9382850}.
Protein families：Protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily