K22E_MOUSE   Q3TTY5


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UniProt:Q3TTY5

Recommended name:Keratin, type II cytoskeletal 2 epidermal

EC number:

Alternative names:(Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)

Cleaved into:

GeneID:16681

Gene names  (primary ):Krt2

Gene names  (synonym ):K2e Krt2-17 Krt2a

Gene names  (ORF ):

Length:707

Mass:70923

Sequence:MSCQISCRSRRGGGGGGGGGFRGFSSGSAVVSGGSRRSNTSFSCISRHGGGRGGSGGGGFGSQSLVGLGGYKSISSSVAGNSGGYGGSSFGGSSGFGGGRGFGGGQGFGGSGGFGGGSGFGGGQGFGGGSRFGGGSGFGGGGFGGGSFGGGRFGGGPGGFGGPGGFPGGGIHEVSVNQSLLQPLDVKVDPEIQNVKSQEREQIKTLNNKFASFIDKVRFLEQQNQVLRTKWELLQQLDVGSRTTNLDPIFQAYIGMLKKQVDRLSAERTSQESELNNMQDLVEDFKKKYEDEINKRTSAENDFVTIKKDVDSCYMDKTELQARLDILAQEVNFLRTLYDAELSQLQQDVTDTNVILSMDNNRNLDLDSIIAEVQNQYEMIAHKSKAESEELYHSKYEELQVTAVKHGDSLKEIKMEISELNRTIQRLQGEISHVKKQCKGVQDSIADAEQRGEHAIKDARGKLTDLEEALQQCREDLARLLRDYQELMNTKLSLDVEIATYRKLLEGEECRMSGDFSDNVSVSITSSTISSSVASKTGFGSGGQSSGGRGSYGGRGGGGGGGSTYGSGGRSSGSRGSGSGSGGGGYSSGGGSRGGSGGGYGSGGGSRGGSGGGYGSGGGSGSGGGYSSGGGSRGGSGGGGVSSGGGSRGGSSSGGGSRGGSSSGGGGYSSGGGSRGGSSSGGAGSSSEKGGSGSGEGCGSGVTFSFR

Tissue specificity:Expressed predominantly in the suprabasal layers of the plantar epidermis outside of the footpads (at protein level) (PubMed:26603179). Expressed mainly in the middle spinous and granular cells of the epidermis of adult tail, nipple and footsole skin. Also found in ear. {ECO:0000269|PubMed:15118396, ECO:0000269|PubMed:2448177, ECO:0000269|PubMed:26603179, ECO:0000269|PubMed:7508961}.

Induction:

Developmental stage:Induction occurs during the first 2 weeks after birth, being first observed in the epidermis of tail then the footpad and later in the ear. {ECO:0000269|PubMed:2448177}.

Protein families:Intermediate filament family


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