IL23A molecular target information overview

Overview of IL23A molecular targets

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of the IL-12p40 subunit and the IL-23p19 subunit, of which the p40 subunit is shared by IL-23 and IL-12. The functional receptors for IL-23 have been identified and consist of IL-12Rβ1 and IL-23R. IL-23 plays a role in the immune response of type 1 polarized T cells. Although IL-12 can strongly activate naive T cells, initial reports suggest that IL-23 can preferentially act on memory T cells to promote their secretion of IFN-γ and proliferation, suggesting that IL-23 has an important role in controlling bacterial infections. IL-23 has been further described as a key cytokine controlling inflammation in peripheral tissues. Overexpression of p19 is associated with inflammation in multiple organs and epithelial tissues including the skin. IL-23 is involved in inflammation of the central nervous system and autoimmune diseases.

Human IL23A Molecular Target Information

Molecular name: IL23A, interleukin 23 subunit alpha

Alias:

• IL-23
• IL-23 subunit alpha
• IL-23-A
• IL-23A
• IL-23p19
• IL23P19
• interleukin 23 p19 subunit
• interleukin 23, alpha subunit p19
• interleukin-23 subunit alpha
• interleukin-23 subunit p19
• interleukin-six, G-CSF related factor
• JKA3 induced upon T-cell activation
• MGC79388
• P19
• SGRF

Gene sequence:NCBI_Gene: 51561

Protein sequence:UniProtKB: Q9NPF7

Human IL23A target molecular function (prediction)

Contributes to interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Part of interleukin-23 complex.

Mouse Il23a molecular target information

Molecular name: Il23a, interleukin 23, alpha subunit p19

Alias:

• IL-23
• IL-23p19
• p19

Gene sequence:NCBI_Gene: 83430

Protein sequence:

• UniprotKB: Q9EQ14

Mouse Il23a target molecular function (prediction)

Contributes to interleukin-23 receptor binding activity. Involved in positive regulation of defense response to virus by host; positive regulation of immune response; and positive regulation of neutrophil chemotaxis. Acts upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Part of interleukin-23 complex. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL23A (interleukin 23 subunit alpha).

Rat Il23a molecular target information

Molecular name: Il23a, interleukin 23 subunit alpha

Alias:

• IL-23 subunit alpha
• IL-23-A
• IL-23p19
• Interleukin 23, alpha subunit p19
• interleukin-23 subunit alpha
• interleukin-23 subunit p19
• MGC114275

Gene sequence:NCBI_Gene: 155140

Protein sequence:UniProtKB: Q91Z84

Rat Il23a target molecular function (prediction)

Predicted to enable cytokine activity. Predicted to contribute to interleukin-23 receptor binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to act upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Orthologous to human IL23A (interleukin 23 subunit alpha).