SPEG_MOUSE Q62407
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UniProt:Q62407
Recommended name：Striated muscle-specific serine/threonine-protein kinase
EC number：EC 2.7.11.1
Alternative names：(Aortic preferentially expressed protein 1) (APEG-1)
Cleaved into：
GeneID：11790
Gene names (primary )：Speg
Gene names (synonym )：Apeg1 Kiaa1297
Gene names (ORF )：
Length：3262
Mass：354343
Sequence：MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGRGVLVTGDGAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLSWFRDGQLLPPPAPEPSCLWLRSCGAQDAGVYSCSAQNERGQASCEAVLTVLEVRDSETAEDDISDVPGTQRLELRDDRAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRPLPGSPRQAQTTGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSIPPSGLHREEPDLQPQPASDALRPRPALPPPSKSALLPPPSPRVGKRALPGPSTQPPATPTSPHRRAQEPSLPEDITTTEEKRGKKPKSSGPSLAGTVESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSEGGAAWGTPEASQEELRSPRGSVAERRRLFQQKAASLDERTRQRSATSDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAATQPPPPSGAGKSGDEPGRPRSRGPVGRTEPGEGPQQEIKRRDQFPLTRSRAIQECRSPVPPYTADPPESRTKAPSGRKREPPAQAVRFLPWATPGVEDSVLPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGTRSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNMVVAPGADVLLKCIITANPPPQVSWKKDGSMLHSEGRLLIRAEGERHTLLLREAQAADAGSYTATATNELGQATCASSLAVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKLSPSQDHDSSDSSSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNEGDNLRLRQDGGLHSLHIARVGSEDEGLYEVSATNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEHGDLERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPEVVAVTGRMVTLSWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPAWAATGLKKGIQHIFRVLSSSGKSSSKPSAPSEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEAQVVWRSCRGALLEARTGVYELSQPDDDQYCLRICRVSRRDLGPLTCSARNRHGTKACSVTLELAEAPRFESIMEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVLLSAGSQDGGVYTCTARNLAGEVSCKAELSVLSAQTAMEVEGVGEDEEHRGRRLSDYYDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHGCVLYFHEAFERRRGLVIVTELCTEELLERMARKPTVCESETRTYMRQVLEGICYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVAMPRRQPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPEAGAATPMDWQEQERTPSKDQEAPSPEALPSPGQESPDGPSPRRPELRRGSSAESALPRVGSREPGRSLHKAASVELPQRRSPSPGATRLTRGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPPESRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSETQPPSPARPSVPKLSITKSPEPSAVTSRDSPQPPEPQPVPEKVPEPKPEPVRAAKPAQPPLALQMPTQPLTPYAQIMQSLQLSSPTLSPQDPAVPPSEPKPHAAVFARVASPPPGVSEKRVPSARTPPVLAEKARVPTVPPRPGSSLSGSIENLESEAVFEAKFKRSRESPLSRGLRLLSRSRSEERGPFRGAEDDGIYRPSPAGTPLELVRRPERSRSVQDLRVAGEPGLVRRLSLSLSQKLRRTPPGQRHPAWESRSGDGESSEGGSSARASPVLAVRRRLSSTLERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRATSEGESLRRLGVPHNQLGSQTGATTPSAESLGSEASGTSGSSAPGESRSRHRWGLSRLRKDKGLSQPNLSSSVQEDLGHQYVPSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARIPGKLAPPEVPQTYHDTALVVWKPGDGRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTQLPVGVTVRFRVACSNRAGQGPFSNPSEKVFIRGTPDSPAQPAAAPRDAPVTSGPTRAPPPDSPTSLAPTPALAPPASQASTLSPSTSSMSANQALSSLKAVGPPPATPPRKHRGLLATQQAEPSPPSIVVTPSEPRSFVPDTGTLTPTSSPQGVKPAPSSTSLYMVTSFVSAPPAPQAPAPEPPPEPTKVTVRSLSPAKEVVSSPTPESTTLRQGPPQKPYTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGSP
Tissue specificity：Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. Isoform 1 and isoform 4 are expressed in cardiomyocytes of the developing heart. {ECO:0000269|PubMed:10973969, ECO:0000269|PubMed:19118250, ECO:0000269|PubMed:8663449}.
Induction：Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype. {ECO:0000269|PubMed:8663449}.
Developmental stage：
Protein families：Protein kinase superfamily, CAMK Ser/Thr protein kinase family