OPN4_MOUSE Q9QXZ9
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UniProt:Q9QXZ9
Recommended name：Melanopsin
EC number：
Alternative names：(Opsin-4)
Cleaved into：
GeneID：30044
Gene names (primary )：Opn4
Gene names (synonym )：Mop Mopn
Gene names (ORF )：
Length：521
Mass：57231
Sequence：MDSPSGPRVLSSLTQDPSFTTSPALQGIWNGTQNVSVRAQLLSVSPTTSAHQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMFIINLAVSDFLMSVTQAPVFFASSLYKKWLFGETGCEFYAFCGAVFGITSMITLTAIAMDRYLVITRPLATIGRGSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMTFTPQVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRQRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGRKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSQNLEDGELKASSSPQVQRSKTPKVPGPSTCRPMKGQGARPSSLRGDQKGRLAVCTGLSECPHPHTSQFPLAFLEDDVTLRHL
Tissue specificity：Expressed in the retinal pigment epithelium and ganglion cell layer (at protein level) (PubMed:10632589, PubMed:30240620, PubMed:31607531). Also expressed in amacrine cell layers of the retina (PubMed:10632589). Weakly expressed in vibrissae, and tail (PubMed:31607531). {ECO:0000269|PubMed:10632589, ECO:0000269|PubMed:30240620, ECO:0000269|PubMed:31607531}.; [Isoform 1]: Observed with processes in the outer strata of inner plexiform layer (IPL) close to the inner nuclear layer (INL) or is found to be bistratified with processes located both in the inner (ON) or outer (OFF) layers of the IPL (at protein level) (PubMed:19793992). A second population of isoform 1 is identified in processes which are confined to the inner layer of the IPL near to the ganglion cell layer (GCL) (at protein level) (PubMed:19793992). {ECO:0000269|PubMed:19793992}.; [Isoform 2]: About 40 times more abundant than isoform 1 in the retina (at protein level) (PubMed:19793992). Isoform 2 is involved in processes localized to the outer IPL or is bistratified with processes in both the inner and outer layers of the IPL (at protein level) (PubMed:19793992). Isoform 2 is absent in the processes confined only to the inner layer of the IPL (at protein level) (PubMed:19793992). {ECO:0000269|PubMed:19793992}.
Induction：
Developmental stage：Expressed in the inner retina at postnatal day 5 (P5), and expressed in retinal ganglion cells at P12. {ECO:0000269|PubMed:30936473}.
Protein families：G-protein coupled receptor 1 family, Opsin subfamily