MUC16 molecular target information overview
Overview of MUC16 molecular targets
Cancer antigen 125 or carbohydrate antigen 125 (CA125), also known as mucin 16 or MUC16, is a protein that is encoded by the MUC16 gene in humans. MUC16 is a member of the mucin family of glycoproteins. It is a component of the epithelium of the ocular surface, respiratory tract, and female reproductive tract. As MUC16 is heavily glycosylated, it creates a hydrophilic environment at the apical membrane of epithelial cells, acting as a lubricating barrier against foreign particles and infectious agents. In addition, the cytoplasmic end of MUC16 has been shown to interact with the cytoskeleton by binding to members of the ERM protein family. The expression of MUC16 is altered in dry eye, cystic fibrosis, and several cancers.
Human MUC16 Molecular Target Information
Molecular name: MUC16, mucin 16, cell surface associated
Alias:
- CA-125
- CA125
- CA125 ovarian cancer antigen
- cancer antigen 125
- FLJ14303
- MUC-16
- mucin 16
- mucin-16
- mucin-16 long isoform
- mucin-16 short isoform
- ovarian cancer-related tumor marker CA125
- ovarian carcinoma antigen CA125
Gene sequence:NCBI_Gene: 94025
Protein sequence:UniProtKB: Q8WXI7
Human MUC16 target molecular function (prediction)
Predicted to act upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Is extrinsic component of membrane. Implicated in ovarian cancer. Biomarker of Sjogren's syndrome; cholangiocarcinoma; dry eye syndrome; keratoconjunctivitis; and pancreatic cancer.
Mouse Muc16 molecular target information
Molecular name: Muc16, mucin 16
Alias:
- 1110008I14Rik
- gene model 1480, (NCBI)
- Gm1480
- Gm21044
- LOC385009
- predicted gene, 21044
- RIKEN cDNA 1110008I14 gene
Gene sequence:NCBI_Gene: 73732
Protein sequence:
- UniprotKB: A0A140LI05
- UniprotKB: A0A140LIA5
- UniprotKB: A0A140LJ72
- UniprotKB: Q9D1H1
Mouse Muc16 target molecular function (prediction)
Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated).
Rat Muc16 molecular target information
Molecular name: Muc16, mucin 16, cell surface associated
Alias:
- LOC315451
- mucin 16
- mucin-16
- RGD1308422
- similar to ovarian cancer related tumor marker CA125
Gene sequence:NCBI_Gene: 315451
Protein sequence: None
Rat Muc16 target molecular function (prediction)
Predicted to act upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in extracellular space. Biomarker of ovarian carcinoma. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated).