DEAF1_MOUSE Q9Z1T5
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q9Z1T5
Recommended name：Deformed epidermal autoregulatory factor 1 homolog
EC number：
Alternative names：(Nuclear DEAF-1-related transcriptional regulator) (NUDR)
Cleaved into：
GeneID：54006
Gene names (primary )：Deaf1
Gene names (synonym )：
Gene names (ORF )：
Length：566
Mass：59633
Sequence：MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSRDEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAAFAEVTTVTVANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSEHRSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDTERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVAV
Tissue specificity：Ubiquitously expressed during embryogenesis, with higher expression in regions of the central nervous system, dorsal root ganglia, submandibular gland, epidermis and breast. In 12-week-old NOD mice, expression of isoform 2 is sevenfold higher in lymph node stromal elements than in T-cells and tenfold higher than in B-cells. {ECO:0000269|PubMed:9860983}.
Induction：
Developmental stage：Expressed at all stages of mammary gland development with slightly higher levels observed during pregnancy and lactation. At 4 weeks, expression levels of isoform 1 and isoform 2 do not differ in pancreatic lymph nodes of nonobese diabetic (NOD) mice compared to NOD.B10 mice which do not develop diabetes. However, at 12 weeks, expression of isoform 1 is down-regulated while expression of isoform 2 is up-regulated in NOD mice but not in NOD.B10. There is no difference in expression levels at 12 weeks in spleen. {ECO:0000269|PubMed:18826651, ECO:0000269|PubMed:19668219}.
Protein families：