CASP2_MOUSE P29594
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UniProt:P29594
Recommended name：Caspase-2
EC number：EC 3.4.22.55
Alternative names：(CASP-2) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1)
Cleaved into：Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12
GeneID：12366
Gene names (primary )：Casp2
Gene names (synonym )：Ich1 Nedd-2 Nedd2
Gene names (ORF )：
Length：452
Mass：50661
Sequence：MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHVLPPLSCDYDTSLPFSVCESCPPHKQLRLSTDATEHSLDNGDGPPCLLVKPCTPEFYQAHYQLAYRLQSQPRGLALVLSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAHRVTDSCVVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHTQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT
Tissue specificity：High level expression seen in the embryonic CNS, liver, lung, kidney, small intestine, and hair follicles of vibrissae. Moderate expression seen in the skin, oral mucosa, skeletal muscle, submandibular gland and thymus. In the adult, it is highly expressed in spleen, lung and kidney. Moderately in the brain, heart, testis, liver. Low levels in the thymus, skeletal muscle, ovary and gut.
Induction：
Developmental stage：During embryonic development is highly expressed in several types of mouse tissue undergoing high rates of programmed cell death such as central nervous system and kidney.
Protein families：Peptidase C14A family