STK11_RAT D4AE59
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UniProt:D4AE59
Recommended name:Serine/threonine-protein kinase STK11 Curated
EC number:EC:2.7.11.1
Alternative names:Liver kinase B1 homolog (LKB1)
Cleaved into:
GeneID:
Gene names (primary ):Stk11
Gene names (synonym ):Lkb1
Gene names (ORF ):
Length:436
Mass:49,246
Sequence:MDVADPQPLGLFPEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPCDCAPPLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRSMTVVPYLEDLHGRAEEEEDEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKAVCVNGTEPQLSSKVKPEGRPGAANPARKVCSSNKIRRLSACKQQ
Tissue specificity:Expressed in brain, heart, testis, skeletal muscle and spleen, and weakly in liver and kidney. Isoform 1 is expressed at highest levels in the brain. Isoform 2 is expressed at highest levels in the testis, primarily in postmitotic developing germ cells (at protein level). 1
Induction:
Developmental stage:Isoform 2 is expressed in testis from 30 days of age, with significantly increased levels by 60 days; this corresponds to the stage when haploid spermatids appear. 1
Protein families: