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TIGIT molecular target information overview


  • Molecular name: TIGIT, T cell immunoreceptor with Ig and ITIM domains
  • Gene family: V-set domain containing
  • Other names: FLJ39873; DKFZp667A205
  • Former names: VSIG9; VSTM3
  • Alias: VSIG9, VSTM3


    • Overview of TIGIT molecular targets


    TIGIT, the full name of which is T cell immunoglobulin and ITIM domain protein, also known as Vsig9, Vstm3 or WUCAM, is a member of the poliovirus receptor (PVR)/Nectin family and a member of the immunoglobulin superfamily. It is composed of the extracellular immunoglobulin (IgV) domain, the type I transmembrane domain, and the intracellular ITIM and immunoglobulin tyrosine tail (ITT) motif structure. TIGIT is limited to expression on lymphocytes, among which the most expressed are CD4+ regulatory T cells, CD4+ follicular helper T cells, CD8+ effector T cells and natural killer (NK) cells.


    Human TIGIT Molecular Target Information


    Molecular name:TIGIT, T cell immunoreceptor with Ig and ITIM domains


    Alias:

    • DKFZp667A205
    • FLJ39873
    • T-cell immunoreceptor with Ig and ITIM domains
    • V-set and immunoglobulin domain containing 9
    • V-set and immunoglobulin domain-containing protein 9
    • V-set and transmembrane domain containing 3
    • V-set and transmembrane domain-containing protein 3
    • VSIG9
    • VSIG9, VSTM3
    • VSTM3
    • Washington University cell adhesion molecule
    • WUCAM

    Gene sequence:NCBI_Gene: 201633

    Protein sequence:UniProtKB: Q495A1


    Human TIGIT target molecular function (prediction)


    Enables identical protein binding activity and signaling receptor binding activity. Involved in negative regulation of interleukin-12 production and positive regulation of interleukin-10 production. Acts upstream of or within negative regulation of T cell activation. Located in cell surface.


    Mouse Tigit molecular target information


    Molecular name: Tigit, T cell immunoreceptor with Ig and ITIM domains


    Alias:

    • ENSMUSG00000071552
    • predicted gene, ENSMUSG00000071552
    • V-set and transmembrane domain containing 3
    • Vstm3


    Gene sequence:NCBI_Gene: 100043314

    Protein sequence:


    Mouse Tigit target molecular function (prediction)


    Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).


    Rat Tigit molecular target information


    Molecular name: Tigit, T cell immunoreceptor with Ig and ITIM domains

    Alias:

    • LOC363784
    • RGD1563191
    • similar to hypothetical protein
    • T-cell immunoreceptor with Ig and ITIM domains

    Gene sequence:NCBI_Gene: 363784

    Protein sequence:UniProtKB: D3ZTQ2


    Rat Tigit target molecular function (prediction)


    Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in negative regulation of T cell activation; negative regulation of interleukin-12 production; and positive regulation of interleukin-10 production. Predicted to be integral component of membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).