PSB8_MOUSE P28063
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UniProt:P28063
Recommended name：Proteasome subunit beta type-8
EC number：EC 3.4.25.1
Alternative names：(Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i)
Cleaved into：
GeneID：16913
Gene names (primary )：Psmb8
Gene names (synonym )：Lmp7 Mc13
Gene names (ORF )：
Length：276
Mass：30260
Sequence：MALLDLCGAARGQRPEWAALDAGSGGRSDPGHYSFSAQAPELALPRGMQPTAFLRSFGGDQERNVQIEMAHGTTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGEAAL
Tissue specificity：Detected in liver (at protein level). Expressed in spleen, thymus, lung, liver, heart and, at a very low level, in kidney. Not expressed in brain nor testis. {ECO:0000269|PubMed:22341445, ECO:0000269|PubMed:8406612}.
Induction：Up-regulated by interferon gamma (at protein level). Up-regulated by IRF1. Down-regulated in spleen by deoxynivalenol (DON), a mycotoxin that alters immune functions. Down-regulated by the selective inhibitor PR-957. Up-regulated by heat shock treatment. Down-regulated by EGR1 in neuronal cells. {ECO:0000269|PubMed:15371230, ECO:0000269|PubMed:15907481, ECO:0000269|PubMed:16452686, ECO:0000269|PubMed:17142736, ECO:0000269|PubMed:19525961}.
Developmental stage：
Protein families：Peptidase T1B family